Antiretroviral Adherence and Development of Drug Resistance Are the Strongest Predictors of Genital HIV-1 Shedding among Women Initiating Treatment
dc.contributor.author | Graham, Susan M | |
dc.contributor.author | Masese, Linnet | |
dc.contributor.author | Gitau, Ruth | |
dc.contributor.author | Jalalian-Lechak, Zahra | |
dc.contributor.author | Richardson, Barbra A | |
dc.contributor.author | Peshu, Norbert | |
dc.contributor.author | Mandaliya, Kishor | |
dc.contributor.author | Kiarie, James N | |
dc.contributor.author | Jaoko, Walter | |
dc.contributor.author | Ndinya-Achola, Jeckoniah | |
dc.contributor.author | Overbaugh, Julie | |
dc.contributor.author | McClelland, R Scott | |
dc.date.accessioned | 2014-08-15T09:36:56Z | |
dc.date.available | 2014-08-15T09:36:56Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | J Infect Dis. (2010) 202 (10): 1538-1542. doi: 10.1086/656790 | en_US |
dc.identifier.uri | http://jid.oxfordjournals.org/content/202/10/1538.short | |
dc.identifier.uri | http://hdl.handle.net/11295/73792 | |
dc.description.abstract | Persistent genital human immunodeficiency virus type 1 (HIV-1) shedding among women receiving antiretroviral therapy (ART) may present a transmission risk. We investigated the associations between genital HIV-1 suppression after ART initiation and adherence, resistance, pretreatment CD4 cell count, and hormonal contraceptive use. First-line ART was initiated in 102 women. Plasma and genital HIV-1 RNA levels were measured at months 0, 3, and 6. Adherence was a strong and consistent predictor of genital HIV-1 suppression (P < .001), whereas genotypic resistance was associated with higher vaginal HIV-1 RNA level at month 6 (P = .04). These results emphasize the importance of adherence to optimize the potential benefits of ART for reducing HIV-1 transmission risk. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.title | Antiretroviral Adherence and Development of Drug Resistance Are the Strongest Predictors of Genital HIV-1 Shedding among Women Initiating Treatment | en_US |
dc.type | Article | en_US |
dc.type.material | en | en_US |
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Faculty of Health Sciences (FHS) [10385]