Browsing Journal Articles by Author "Tapia, K"
Now showing items 1-10 of 10
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Clinical and Virologic Manifestations of Primary Epstein-Barr Virus (EBV) Infection in Kenyan Infants Born to HIV-Infected Women.
Slyker, JA; Casper, C; Tapia, K; Richardson, B; Bunts, L; Huang, ML; Maleche-Obimbo, E; Nduati, RW; John-Stewart, G (University of NairobiDepartment of Pediatrics and Child Health, School of Medicine, University of Nairobi, 2013-06)Background. Human immunodeficiency virus (HIV) infection is a risk factor for Epstein-Barr virus (EBV)-associated lymphomas. Characterizing primary infection may elucidate risk factors for malignancy. Methods. To describe ... -
Consistency of Mycobacterium tuberculosis-specific interferon-gamma responses in HIV-1-infected women during pregnancy and postpartum.
Jonnalagadda, SR; Brown, E; Lohman-Payne, B; Wamalwa, D; Farquhar, C; Tapia, K; Cranmer, LM; John-Stewart, GC (University of Nairobi.Department of Paediatrics, 2012)Background: We determined the consistency of positive interferon-gamma (IFN-γ) release assays (IGRAs) to detect latent TB infection (LTBI) over one-year postpartum in HIV-1-infected women. Methods: Women with positive IGRAs ... -
The impact of HIV-1 infection and exposure on natural killer (NK) cell phenotype in Kenyan infants during the first year of life
Slyker, JA; Lohman-Payne, B; John-Stewart, GC; Dong, T; Mbori-Ngacha, DA; Tapia, K; Atzberger, A; Taylor, S; Rowland-Jones, SL; Blish, CA. (College of health science,University of Nairobi, 2012)Natural killer (NK) cells play an important role in the containment of HIV replication during primary infection, though their functions are impaired during chronic HIV infection. Infants experience more rapid HIV disease ... -
Lipid Changes in Kenyan HIV-1-Infected Infants Initiating Highly Active Antiretroviral Therapy by One Year of Age.
Langat, A; Benki-Nugent, S; Wamalwa, D; Tapia, K; Ngugi, Elizabeth N; Diener, L; Richardson, BA; Melvin, A; John-Stewart, GC (Department of Paediatrics, 2013-02)BACKGROUND:: Early highly active antiretroviral therapy (HAART) is recommended for HIV-1 infected infants. There are limited data on lipid changes during infant HAART. METHODS:: Non-fasting total (TC), low density lipoprotein ... -
Male, Mobile, and Moneyed: Loss to Follow-Up vs. Transfer of Care in an Urban African Antiretroviral Treatment Clinic.
Marson, KG; Tapia, K; Kohler, P; McGrath, CJ; John-Stewart, Grace C.; Richardson, BA; Njoroge, JW; Kiarie, JN; Sakr, SR; Chung, MH. (University of NairobiDepartment of Medical Microbiology,, 2013-10)OBJECTIVES: The purpose of this study was to analyze characteristics, reasons for transferring, and reasons for discontinuing care among patients defined as lost to follow-up (LTFU) from an antiretroviral therapy (ART) ... -
Nevirapine resistance in previously nevirapine-unexposed HIV-1 infected Kenyan infants initiating early antiretroviral therapy.
Chohan, B; Tapia, K; Benki-Nugent, S; Khasimwa, B; Ngayo, MO; Maleche-Obimbo, E; [et.al] (University of Nairobi, 2015)Nevirapine (NVP) resistance occurs frequently in infants following NVP use in prevention of mother-to-child transmission (PMTCT) regimens. However, among previously NVP-unexposed infants treated with NVP-ART, the development ... -
Oligonucleotide ligation assay detects HIV drug resistance associated with virologic failure among antiretroviral-naive adults in Kenya
Chung, MH; Beck, IA; Dross, S; Tapia, K; Kiarie, JN; Richardson, BA; Overbaugh, J; Sakr, SR; John-Stewart, GC; Frenkel, LM (University of Nairobi, 2014-11)BACKGROUND: Transmitted drug resistance (TDR) is increasing in some areas of Africa. Detection of TDR may predict virologic failure of first-line nonnucleoside reverse transcriptase inhibitor (NNRTI)-based antiretroviral ... -
Pooled HIV-1 RNA Viral Load Testing for Detection of Antiretroviral Treatment Failure in Kenyan children.
Chohan, B.H,; Tapia, K; Merkel, M,; Kariuki, A.C; Khasimwa, B; Olago, A,; Gichohi, R; Obimbo, E.M; Wamalwa, D.C. (Departments of Medical Microbiology, University of Nairobi, Nairobi, KenyaDepartments of Medicine, University of Washington, Seattle, WA, 2013)Pooled viral load (VL) testing with two different testing strategies was evaluated as a potential cost-saving method to monitor antiretroviral therapy (ART) in HIV-infected children receiving ART in a resource-limited ... -
Survival benefit of early infant antiretroviral therapy is compromised when diagnosis is delayed.
Wamalwa, D; Benki-Nugent, S; Langat, A; Tapia, K; Ngugi, Elizabeth N; Slyker, JA; Richardson, BA; John-Stewart, GC (University of NairobiDepartment of Paediatrics, 2012-07)Late presentation is common among African HIV-1-infected infants. Incidence and correlates of mortality were examined in 99 infants with HIV-1 diagnosis by 5 months of age. Twelve-month survival was 66.8% (95% confidence ... -
Tuberculosis interferon-gamma responses in the breast milk of human immunodeficiency virus infected mothers.
Cranmer, LM; Kanyugo, M; Lohman-Payne, B; Tapia, K; John-Stewart, GC (University of Nairobi, 2015-12)Tuberculosis (TB) cellular immune responses were examined in the breast milk of human immunodeficiency virus infected mothers using the T-SPOT(®). TB interferon-gamma release assay (IGRA). Positive TB interferon-gamma ...