Browsing Journal Articles by Author "Taylor, G"
Now showing items 1-7 of 7
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Effect of experimentally-induced hepatic cirrhosis on the pharmacokinetics of orally administered praziquantel in the rat
Kokwaro, GO; Taylor, G (University of Nairobi.Department of Pharmaceutics & Pharmacy Practice, Faculty of Pharmacy, College of Health Sciences, 1990)The effects of pretreatment with the hepatotoxin, thioacetamide, on the pharmacokinetics of praziquantel, a broad spectrum schistosomicidal agent with a high hepatic clearance, were studied in male Wistar rats. Animals ... -
Effect of oxamniquine on hepatic drug metabolising capacity in the mouse
Kokwaro, GO; Taylor, G (University of Nairobi.School of Pharmacy, 1987) -
First-pass metabolism of oxamniquine: a quantitative study in the rabbit
Kokwaro, GO; Taylor, G (University of Nairobi.School of Pharmacy, 1986) -
Oxamniquine pharmacokinetics following oral administration to healthy volunteers
Kokwaro, GO; Taylor, G (University of Nairobi.School of Pharmacy, 1985) -
Oxamniquine pharmacokinetics in healthy Kenyan African volunteers
Kokwaro, GO; Taylor, G (University of Nairobi.Department of Pharmacy, University of Nairobi, Kenya, 1991-05)Oxamniquine pharmacokinetics were studied following oral administration of 750, 1000 mg or 1250 mg (equivalent to approximately 15 mg/kg) to five healthy Kenyan African volunteers. Peak plasma concentrations ranging between ... -
Partitioning of oxaminiquine into brain tissue following intravenous administration to female Wistar rats
Kokwaro, GO; Taylor, G (University of Nairobi.Department of Pharmaceutics & Pharmacy Practice, Faculty of Pharmacy, College of Health Sciences, 1990)Brain and plasma concentrations of oxaminiquine were determined following intravenous dosing (15 mg kg-1) in female Wistar rats. Maximum brain concentrations were achieved one hour after dosing and at all sampling times ... -
Pharmacokinetics of oxamniquine in rabbit and rat
Kokwaro, GO; Indalo, Anne A; Taylor, G (University of Nairobi.Department of Pharmacy, College of Health Sciences, University of Nairobi, Kenya, 1996)The pharmacokinetics of the schistosomicidal agent oxamniquine (6-hydroxmethyl-2-isopropylaminomethyl-7-nitro-1,2,3,4-tetra hydroquinoline) were studied in 8 (4 male, 4 female) New Zealand White rabbits and 5 female Wistar ...