Browsing Journal Articles by Author "Terefe, Ermias M"

Now showing items 1-4 of 4

    • Anti-HIV crotocascarin ω from Kenyan Croton dichogamus 

      Terefe, Ermias M; Okalebo, Faith A; Derese, Solomon; Muriuki, Joseph; Mas-Claret, Eduard; Langat, Moses K (University of Nairobi, 2022-10)
      An anti-HIV methanol-soluble fraction of a 1:1 CH2Cl2:CH3OH extract of twigs of a Kenyan Croton dichogamus yielded seven compounds, the new crotocascarin ω (1), the known β-oplopanone (2), dihydroconiferyl acetate (3), ...

    • Constituents of Croton Megalocarpus With Potential Anti-hiv Activity 

      Terefe, Ermias M; Okalebo, Faith A; Derese, Solomon; Muriuki, Joseph; Rotich, Winnie; Mas-Claret, Eduard; Sadgrove, Nicholas; Padilla-González, Guillermo F; Prescott, Thomas A K; Siddique, Holly; Langat, Moses K (University of Nairobi, 2022)
      Reported herein is an anti-HIV monochlorinated compound, 1β-acetoxy-3β-chloro-5α,6α-dihydroxycrotocascarin L (1), of the rare crotofolane diterpenoid class. Compound 1, a suspected artifact of extraction, along with the ...

    • Cytotoxicity and Anti-hiv Activities of Extracts of the Twigs of Croton Dichogamus Pax 

      Terefe, Ermias M; Okalebo, Faith A; Derese, Solomon; Gaber, El-Saber B; Amal, Youssef; Alorabi, Mohammed; Muriuki, Joseph (University of Nairobi, 2022-02)
      Background: Acquired immunodeficiency syndrome (AIDS) is a clinical syndrome resulting from infection with human immunodeficiency virus (HIV), which causes profound immunosuppression. Anti-HIV drugs that are currently ...

    • In Vitro Anti-hiv and Cytotoxic Effects of Pure Compounds Isolated From Croton Macrostachyus Hochst. Ex Delile 

      Terefe, Ermias M; Okalebo, Faith A; Derese, Solomon; Langat, Moses K; Mas-Claret, Eduard; Aljarba, Nada H; Alkahtani, Saad; Batiha, Gaber E; Ghosh, Arabinda; El-Masry, Eman A; Muriuki, Joseph (University of Nairobi, 2022)
      Croton macrostachyus is an important plant in traditional African medicine, widely utilized to treat a variety of diseases. In Kenya, HIV-infected patients use leaf and root decoctions of the plant as a cure for cough, ...