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Human leukocyte antigen-DQ alleles and haplotypes and their associations with resistance and susceptibility to HIV-1 infection
(2008)
Objectives: To determine the association of DQ antigens with resistance and susceptibility
to HIV-1.
Design: Despite repeated exposure to HIV-1, a subset of women in the Pumwani Sex
Worker cohort established in Nairobi, ...
Mucosal Serpin A1 And A3 Levels In Hiv Highly Exposed Sero-negative Women Are Affected By The Menstrual Cycle And Hormonal Contraceptives But Are Independent Of Epidemiological Confounders.
(University of Nairobi, 2013-01)
OBJECTIVE:
Serpins (serine protease inhibitors) are associated with protection against HIV infection. Here, we characterized mucosal serpin expression in the genital tract of HIV highly exposed sero-negative (HESN) women ...
Cd4+ T Cell Responses In Hiv-exposed Seronegative Women Are Qualitatively Distinct From Those In Hiv-infected Women
(University of Nairobi, 2005-01)
The immune response of human immunodeficiency virus (HIV)-exposed seronegative (ESN) women may be qualitatively different from that in those infected with HIV (HIV(+)). In a cohort of female commercial sex workers in ...
Isolation and identification of Haemophilus ducreyi in a clinical laboratory
(University of Nairobi, 1986-09)
Routine procedures used to isolate Haemophilus ducreyi in a busy laboratory are reported. Identification was based on colony morphology and nutritional and biochemical properties of 120 fresh isolates of H. ducreyi. These ...
Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection.
(, 2000-05)
Certain human leukocyte antigens, by presenting conserved immunogenic epitopes for T cell recognition, may, in part, account for the observed differences in human immunodeficiency virus type 1 (HIV-1) susceptibility. To ...
Identification of three novel human leukocyte antigen alleles, HLA-B58:43 HLA-C03:190 and HLA-DPA101:12 in an East African cohort.
(University of Nairobi, 2013-08)
Three novel human leukocyte antigen (HLA) alleles were identified using a sequence-based typing of HLA class I and class II alleles of 1867 participants from a male circumcision cohort in Kenya. The new alleles were first ...
HIV and Interferon Regulatory Factor 1: A Story of Manipulation and Control.
(University of Nairobi, 2013-11)
Members of the interferon regulatory factor (IRF) family control the expression of numerous proteins, many of which are central to regulating host immune responses. IRF1 is one of the central mediators of the innate and ...
HIV Type 1 Resistance in Kenyan Sex Workers Is Not Associated with Altered Cellular Susceptibility to HIV Type 1 Infection or Enhanced β-Chemokine Production
(1998)
A small group of women (n = 80) within the Nairobi-based Pumwani Sex Workers Cohort demonstrates epidemiologic resistance to HIV-1 infection. Chemokine receptor polymorphisms and β-chemokine overproduction have been among ...
Rapid increase of both HIV-1 infection and syphilis among pregnant women in Nairobi, Kenya
(University of Nairobi, 1992-10)
OBJECTIVE: To determine the prevalence of HIV-1 and syphilis antibodies in a population of pregnant women in Nairobi, Kenya, between 1989 and 1991. METHODS: As part of an ongoing prospective study on the effect of HIV-1 ...