Journal Articles: Recent submissions
Now showing items 2181-2200 of 29885
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Delay Along the Care Seeking Journey of Patients with Microbial Keratitis in Uganda.
(University of Nairobi, 2019)PURPOSE: To describe the care seeking journey and causes of delay among patients with Microbial Keratitis in Uganda. METHODS: A prospective cohort of patients presenting with microbial keratitis at the two main eye ... -
Systematic review of the performance and clinical utility of point of care HIV-1 RNA testing for diagnosis and care.
(University of Nairobi, 2019)BACKGROUND: Point of-care (POC) HIV-1 RNA tests which are accurate and easy to use with limited infrastructure are needed in resource-limited settings (RLS). We systematically reviewed evidence of POC test performance ... -
Health promotion at the workplace setting: a protocol for a systematic review of effectiveness and sustainability of current practice in low-income and middle-income countries.
(University of Nairobi, 2019)INTRODUCTION: Low-income and middle-income countries (LMICs) are experiencing a growing disease burden due to non-communicable diseases (NCDs). Changing behavioural practices, such as diets high in saturated fat, salt ... -
Electronically Divergent Triscyclometalated Iridium(III) 2-(1-naphthyl)pyridine Complexes and Their Application in Three-Component Methoxytrifluoromethylation of Styrene
(University of Nairobi, 2019)A systematic study of the photophysical and electrochemical properties of triscyclometalated homoleptic iridium(III) complexes based on 2-(1-naphthyl)pyridine (npy) ligands is presented. A systematic investigation of ligand ... -
Economic valuation of grazing management practices: discrete choice modeling in pastoral systems of Kenya
(University of Nairobi, 2019)This study estimates the economic contribution of grazing management practices in pastoral systems by specifically undertaking an economic analysis of pastoralists’ preferences for grazing management practices and the ... -
Cytotoxicity Of Fagaramide Derivative And Canthin-6-one From Zanthoxylum (Rutaceae) Species Against Multidrug Resistant Leukemia Cells
(University of Nairobi, 2019)In our continuous search for cytotoxic compounds from the genus Zanthoxylum, chromatographic separation of the MeOH/CH2Cl2 (1:1) extract of Z. chalybeum yielded one new alkamide; 4-(isoprenyloxy)-3-methoxy-3,4-deoxymethy ... -
Cocunut Water And OPTIXcell For Alpine Goat Semen Extension: Comparative Evaluation Of Pot-extension Semen Parameter With And Without Seminal Plasma
(University of Nairobi, 2018)The detrimental effect of reactions of seminal plasma in goat semen with common components of extenders is known and has been the point of focus on developing appropriate extender for goat semen. The current study compared ... -
Effects of Outsourcing Strategy on Procurement Performance among Universities in Kenya
(International Journal of Economics, Commerce and Management, 2014-11)The main objective of the study is to determine the effects of outsourcing strategy on procurement performance among Universities in Kenya. The study found that contracting, comprehensive outsourcing, licensing agreement ... -
First-in-Human Evaluation of the Safety and Immunogenicity of an Intranasally Administered Replication-Competent Sendai Virus-Vectored HIV Type 1 Gag Vaccine: Induction of Potent T-Cell or Antibody Responses in Prime-Boost Regimens.
(2017-01-01)We report the first-in-human safety and immunogenicity assessment of a prototype intranasally administered, replication-competent Sendai virus (SeV)-vectored, human immunodeficiency virus type 1 (HIV-1) vaccine. METHO ... -
Differences in acute retroviral syndrome by HIV-1 subtype in a multicentre cohort study in Africa.
(BMC, 2017-11)Symptoms of acute retroviral syndrome (ARS) may be used to identify patients with acute HIV-1 infection who seek care. ARS symptoms in African adults differ by region. We assessed whether reporting of ARS was associated ... -
Mycoplasma genitalium Infection in Kenyan and US Women.
(Wolters Kluwer, 2018-08)Little is known about the natural history of Mycoplasma genitalium (MG) infection in women. We retrospectively tested archived vaginal fluid samples to assess MG prevalence, incidence, persistence, recurrence and antimicrobial ... -
Prediction of extended high viremia among newly HIV-1-infected persons in sub-Saharan Africa.
(PLoS, 2018-04-03)OBJECTIVE: Prompt identification of newly HIV-infected persons, particularly those who are most at risk of extended high viremia (EHV), allows important clinical and transmission prevention benefits. We sought to determine ... -
Global Distribution of Human Protoparvoviruses
(BMC, 2018-07-07)Development of next-generation sequencing and metagenomics has revolutionized detection of novel viruses. Among these viruses are 3 human protoparvoviruses: bufavirus, tusavirus, and cutavirus. These viruses have been ... -
SOCIAL MEDIA USE BY THE DEAF IN BUSINESS AT NAIROBI, KENYA
(University of Nairobi, 2018-10)Social media for business is the new frontier for deaf Kenyans, due to the information gap they often experience as they navigate a largely speaking and hearing world. This case studyon the use of social media platforms ... -
Live Attenuated Zoster Vaccine Boosts Varicella Zoster Virus (VZV)-Specific Humoral Responses Systemically and at the Cervicovaginal Mucosa of Kenyan VZV-Seropositive Women.
(Oxford Academic, 2018-09-08)BACKGROUND: Attenuated varicella zoster virus (VZV) is a promising vector for recombinant vaccines. Because human immunodeficiencyvirus (HIV) vaccines are believed to require mucosal immunogenicity, we characterized mucosal ... -
Reported willingness to participate in a hypothetical HIV vaccine trial and its translation to actual participation among healthy adults-Experience from Kenya.
(PLoS, 2018-11-02)OBJECTIVE: To evaluate initial reported willingness to participate in a hypothetical HIV vaccine clinical trial and actual participation of volunteers in a longitudinal observational study. METHODS: We recruited HIV ... -
Impact of Standard Bacterial Vaginosis Treatment on the Genital Microbiota, Immune Milieu, and Ex Vivo Human Immunodeficiency Virus Susceptibility.
(Oxford Academic, 2018-09-12)BACKGROUND: Genital immunology is a key determinant of human immunodeficiency virus (HIV) susceptibility. Both factors are modulated by bacterial vaginosis (BV) and, to some extent, by Lactobacillus iners, the genital ... -
Live attenuated varicella-zoster virus vaccine does not induce HIV target cell activation.
(BMC, 2019-02-01)BACKGROUND: Varicella-zoster virus (VZV) is under consideration as a promising recombinant viral vector to deliver foreign antigens including HIV. However, new vectors have come under increased scrutiny, since trials with ... -
Association between vaginal washing and vaginal bacterial concentrations.
(PLoS, 2019-01-24)Vaginal washing is a common practice associated with adverse outcomes including bacterial vaginosis (BV) and HIV infection. Prior studies have not examined the associations between vaginal washing and individual vaginal ... -
Safety and Immunogenicity of a 2-Dose Heterologous Vaccine Regimen With Ad26.ZEBOV and MVA-BN-Filo Ebola Vaccines: 12-Month Data From a Phase 1 Randomized Clinical Trial in Nairobi, Kenya.
(Oxford Academic, 2019-06-05)BACKGROUND: During the 2014 West African Ebola outbreak, Ebola vaccine development was accelerated. The phase 1 VAC52150EBL1003 study was performed to investigate 2-dose heterologous vaccination with Ad26.ZEBOV and ...