Journal Articles: Recent submissions
Now showing items 4721-4740 of 29885
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A New Class of Spermidine-Derived Alkaloids
(2003)Four new alkaloids, dovyalicins A−D, were isolated from Dovyalis macrocalyx. Their structures were established by two-dimensional COSY, NOESY, HSQC, and HMBC NMR experiments as well as chiroptical methods. The compounds, ... -
Contributions of Atlantic ocean to June - August rainfall over Uganda and Western Kenya
(University of Nairobi, 2015)This study investigates the contributions of Atlantic Ocean to June-August rainfall over Uganda and western Kenya (KU). The study utilized the following datasets: precipitation from the Global Precipitation Climatology ... -
Dovyalicin-Type Spermidine Alkaloids from Dovyalis Species
(2006)Phytochemical investigations of Dovyalis abyssinica, D. hebecarpa, and D. macrocalyx revealed two new spermidine-type alkaloids, dovyalicin E (3) and dovyalicin F (4), along with the previously described dovyalicin A (1), ... -
Black cohosh, a menopausal remedy, does not have estrogenic activity and does not promote breast cancer cell growth
(2003)Black cohosh is an increasingly popular alternative to estrogen replacement therapy for the relief of menopausal symptoms, primarily hot flushes. However, an important consideration for long-term therapy is potential ... -
Antimalarial Activity of Some Plants Traditionally used in Meru district of Kenya
(2007)Ten plant extracts commonly used by the Meru community of Kenya were evaluated for the in vitro antiplasmodial, in vivo antimalarial, cytotoxicity and animal toxicity activities. The water and methanol extracts of Ludwigia ... -
In vitro activity of selected medicinal plants in Kenya on Trypanosoma evansi.
(University of Nairobi, 2013)Trypanosomiasis, a protozoan disease causes morbidity and death to humans and severely limits livestock production in endemic areas. It occurs predominantly in Africa, South America and Asia. Although chemotherapy has been ... -
Radiation Acts on the Microenvironment to Affect Breast Carcinogenesis by Distinct Mechanisms that Decrease Cancer Latency and Affect Tumor Type
(2011)Tissue microenvironment is an important determinant of carcinogenesis. We demonstrate that ionizing radiation, a known carcinogen, affects cancer frequency and characteristics by acting on the microenvironment. Using a ... -
Proliferation of estrogen receptor-α-positive mammary epithelial cells is restrained by transforming growth factor-β1 in adult mice
(2005)Transforming growth factor (TGF)-β1 is a potent inhibitor of mammary epithelial proliferation. In human breast, estrogen receptor (ER)-α cells rarely co-localize with markers of proliferation, but their increased frequency ... -
Retinoblastoma in Kenya: survival and prognostic factors
(University of Nairobi, 2015-03)BACKGROUND: In industrialized nations a curative therapy of retinoblastoma can be achieved in a large number of patients due to timely diagnosis and therapy. In developing countries the survival rates are much lower and ... -
Leaf compounds in potential plantation species of Aloe in Kenya
(1997)Many Aloe species are valued for the healing properties associated with the leaf tissues, a factor that has led to over-exploitation of natural populations and endangerment of some local Kenyan species. While trade in ... -
Assessment of Molluscicidal, Cercericidal and Miracicidal Activities of Crude Extracts of Azadirachta indica and Entada leptostachya
(2013)Schistosomiasis infections in humans depend absolutely on the presence of intermediate host. Control of the intermediate host disrupts the cycle of schistosomes stopping transmission of schistosomiasis. Synthetic molluscicides ... -
Antimicrobial Activity, Toxicity and Phytochemical Screening of Four Medicinal Plants Traditionally Used in Msambweni District, Kenya
(2014)This study was designed to evaluate the antimicrobial activity, toxicity and phytochemical composition of organic and aqueous crude extracts of Zanthoxylum chalybeum Engl. (Rutaceae), Adansonia digitata L. (Bombacaceae), ... -
Leveraging cellphones for wayfinding and journey planning in semi-formal bus systems: Lessons from Digital Matatus in Nairobi
(University of Nairobi, 2015-05-21)For many cities in the developing world, public transit consists mainly of semi-formal mini-buses (paratransit). However, little to no digital information is typically available on routes, bus stops, passenger boarding, ... -
Elastic fibre system in the shaft of adult human penis
(University of Nairobi, 2015)Elastic fibres play a central role in functioning of the penis. Detailed animal studies have quantified elastic and collagen fibre content in rat and rabbit penis. Though rabbit model i s similar ... -
Khat (Catha edulis)-induced apoptosis is inhibited by antagonists of caspase-1 and-8 in human leukaemia cells
(2004)Khat chewing is a widespread habit that has a deep-rooted sociocultural tradition in Africa and the Middle East. The biological effects of khat are inadequately investigated and controversial. For the first time, we show ...