Browsing Faculty of Agriculture & Veterinary Medicine (FAg / FVM) by Author "Obregon, Carolina"

Now showing items 1-3 of 3

    • Host cell responses of Salmonella typhimurium infected human dendritic cells 

      Kiama, S G; Dreher, Donatus; Cochand, Laurence; Kok, Menno; Obregon, Carolina; Nicod, Laurent; Gehr, Peter (Department of Genetics and Microbiology, University of Geneva, Geneva, SwitzerlandDepartment of Veterinary Anatomy and Physiology, University of Nairobi, Nairobi, Kenya, 2006)
      Live attenuated Salmonella are attractive vaccine candidates for mucosal application because they induce both mucosal immune responses and systematic immune responses. After breaking the epithelium barrier, Salmonella ...

    • Human alveolar macrophages infected by virulent bacteria expressing SipB are a major source of active interleukin-18 

      Obregon, Carolina; Dreher, Donatus; Kok, Menno; Cochand, Laurence; Kiama, S G; Nicod, Laurent P. (Department of Veterinary Anatomy, University of Nairobi,Division of Pneumology, University Hospital of GenevaDepartment of Genetics and Microbiology, University of Geneva,, 2003)
      Recent publications have demonstrated that the protease caspase-1 is responsible for the processing of prointerleukin 18 (IL-18) into the active form. Studies on cell lines and murine macrophages have shown that the bacterial ...

    • Salmonella virulence factor SipB induces activation and release of IL-18 in human dendritic cells 

      Dreher, Donatus; Kok, Menno; Obregon, Carolina; Kiama, S G; Gehr, Peter; Nicod, Laurent P. (Division of Pneumology, University Hospital of Geneva, SwitzerlandDepartment of Genetics and MicrobiologyDepartment of Medical Biochemistry, University of Geneva, SwitzerlandInstitute of Anatomy, University of Berne, SwitzerlandDepartment of Veterinary Anatomy, University of Nairobi, Kenya, 2002)
      Interleukin-18 (IL-18) plays an important role in innate and acquired immunity, in particular against intracellular pathogens. However, little is known about the microbial factors that trigger IL-18 secretion by dendritic ...