Fc Gamma Receptors IIa and IIIa Genetic Polymorphisms Do Not Predict HIV-1 Disease Progression in Kenyan Women.
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Date
2014Author
JF, Weis
McClelland, RS
Jaoko, W
Mandaliya, KN
Overbaugh, J
Language
enMetadata
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Abstract Genetic polymorphisms of the Fc gamma receptors (FcγR) IIa and IIIa have been implicated in the rate of HIV-1 disease progression, but results are inconsistent. We aimed to determine the association between these polymorphisms and disease progression in a cohort of HIV-1 seroconverters from Mombasa, Kenya. Neither FcγRIIa nor FcγRIIIa genotypes were predictive of set point viral load, viral load increase, CD4 decline, or HIV-1 disease progression (time to CD4 count <200 cells/mm3, death, or treatment initiation). Our results suggest that FcγR polymorphisms might not be an important indicator of viral control and disease progression in this population.
Citation
Weis JF, McClelland RS JMKNOGSMWJ &. "Fc Gamma Receptors IIa and IIIa Genetic polymorphisms do not predict HIV-1 disease progression in Kenyan women. ." AIDS Res Hum Retroviruses (in print). 2014.Collections
- Faculty of Health Sciences (FHS) [10385]