Browsing Faculty of Health Sciences (FHS) by Subject "Antifolate"

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    • Why has the dihydrofolate reductase 164 mutation not consistently been found in Africa yet? 

      Marsh, Kevin; Ward, Steve; Winstanley, Peter; Gilbert, Kokwaro; Nduati, Eunice; Ochong, Edwin; Nzila, Alexis (Department of Pharmaceutics and Pharmacy Practice, 2005)
      Resistance to the antifolate sulfadoxine–pyrimethamine (SP), the current mass-treatment antimalarial drug, is associated with selection of point mutations in dihydrofolate reductase and dihydropteroate synthase. Among these ...