Faculty of Health Sciences (FHS): Recent submissions
Now showing items 1301-1320 of 10385
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Treatment of chronic heart failure in adults at a referral hospital in Kenya: adverse drug reactions and determinants of adherence
(2016)Background: Chronic Heart Failure is a major health problem with a prevalence of between 1 and 12% in USA and Europe, and approximately 5.7% in Sub-Saharan Africa, and has socio-economic relevance owing to its high prevalence, ... -
Determinants of Discontinuation of Contraceptive Methods among Women at Kenyatta National Hospital, Kenya
(2016)Background: Contraceptive use prevalence in Kenya is at 58% according to the 2014 Kenya Demographic Health Survey. Several factors lead to discontinuation and switch of contraceptives. Discontinuation rate as per ... -
Impact of depression on adherence to antiretroviral therapy among HIV/AIDS patients at a Kenyan referral hospital
(2016)Background: Kenya is faced with an increasing challenge of co-morbid psychological and social factors among HIV-Infected patients which has had a profound impact on their medication adherence. A major psychosocial factor ... -
PhD thesis defense
(2016)A thesis oral defence is the culmination of research enquiryon a specific subject or project. The defence provides an opportunity for presentation and sustained argument in support of the findings. This is preceded by ... -
Maternal Neutralization-Resistant Virus Variants Do Not Predict Infant HIV Infection Risk
(2016)Mother-to-child transmission (MTCT) of HIV provides a setting for studying immune correlates of protection. Neutralizing antibodies (NAbs) are suggested to contribute to a viral bottleneck during MTCT, but their role in ... -
High Rates of Exclusive Breastfeeding in Both Arms of a Peer Counseling Study Promoting EBF Among HIV-Infected Kenyan Women
(2016)Background: Exclusive breastfeeding (EBF) is recommended for 6 months after delivery as the optimal infant feeding method and is especially important for prevention of mother-to-child HIV transmission (PMTCT). However, EBF ... -
Room temperature stable carbetocin for the prevention of postpartum haemorrhage during the third stage of labour in women delivering vaginally: study protocol for a randomized controlled trial
(2016)Background Postpartum haemorrhage (PPH) is the leading cause of maternal mortality in low-income countries and contributes to nearly a quarter of maternal deaths globally. The current available interventions for prevention ... -
Uptake and Effectiveness of a Trivalent Inactivated Influenza Vaccine in Children in Urban and Rural Kenya, 2010 to 2012.
(2016)In Africa, recent surveillance has demonstrated a high burden of influenza, but influenza vaccine is rarely used. In Kenya, a country with a tropical climate, influenza has been shown to circulate year-round, like in other ... -
Changes in Vaginal Microbiota and Immune Mediators in HIV-1-Seronegative Kenyan Women Initiating Depot Medroxyprogesterone Acetate
(2016)Background: Depot medroxyprogesterone acetate (DMPA) is associated with HIV acquisition. We studied changes in vaginal microbiota and inflammatory milieu after DMPA initiation. Methods: In a cohort of HIV-negative Kenyan ... -
Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort.
(2016)Broadly neutralizing antibodies (bnAbs) are thought to be a critical component of a protective HIV vaccine. However, designing vaccines immunogens able to elicit bnAbs has proven unsuccessful to date. Understanding the ... -
Schistosoma haematobium and soil-transmitted Helminths in Tana Delta District of Kenya: infection and morbidity patterns in primary schoolchildren from two isolated villages
(2016)Schistosomes and soil-transmitted helminths (STH) (hookworm, Trichuris trichiura and Ascaris lumbricoides) are widely distributed in developing countries where they infect over 230 million and 1.5 billion people, respectively. ... -
Red cell allo- and autoimmunisation in transfused sickle cell and cancer patients in Kenyatta National Hospital, Nairobi, Kenya
(2015)Background: Currently, no data are available on the prevalence of red blood cell (RBC) antibody formation amongst Kenyan patients with multiple transfusion needs, such as patients with sickle cell disease (SCD) or ... -
Glycemic Control in Kenyan Children and Adolescents with Type 1 Diabetes Mellitus
(2015)Background. Type 1 diabetes mellitus (T1DM) is the most common endocrine disorder in children and adolescents worldwide. While data about prevalence, treatment, and complications are recorded in many countries, few data ... -
Clinical pharmacokinetic properties of magnesium sulphate in women with pre-eclampsia and eclampsia
(2016)Background The pharmacokinetic basis of magnesium sulphate (MgSO4) dosing regimens for eclampsia prophylaxis and treatment is not clearly established. Objectives To review available data on clinical pharmacokinetic ... -
Knowledge, attitudes and practices of infertile couples on male participation in infertility management at the Kenyatta National Hospital
(KMA, 2015)Objective: To determine knowledge, attitudes and practices of infertile couples on male involvement in the management of infertility. Design: Hospital based cross-sectional study. Setting: Kenyatta National Hospital, ... -
Urine neutrophil gelatinase-associated lipocalin in asphyxiated neonates: a prospective cohort study
(Springer, 2015)Acute kidney injury (AKI) is the most common complication of perinatal asphyxia. Recent research indicates that urine neutrophil gelatinase-associated lipocalin (NGAL) is an early marker for AKI; yet, there is a paucity ... -
Differential immune responses in mice infected with the tissue-dwelling nematode Trichinella zimbabwensis
(2015)To improve diagnostic tools, immunotherapies and vaccine development for trichinellosis surveillance and control there is a need to understand the host immune responses induced during infection with Trichinella zimbabwensis, ...