Faculty of Health Sciences (FHS): Recent submissions
Now showing items 2541-2560 of 10387
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Unbiased proteomics analysis demonstrates significant variability in mucosal immune factor expression depending on the site and method of collection.
(University of NairobiDepartment of Medical Microbiology, 2013-11)Female genital tract secretions are commonly sampled by lavage of the ectocervix and vaginal vault or via a sponge inserted into the endocervix for evaluating inflammation status and immune factors critical for HIV microbicide ... -
Identification of three novel human leukocyte antigen alleles, HLA-B58:43 HLA-C03:190 and HLA-DPA101:12 in an East African cohort.
(University of NairobiHIV and Human Genetics, National Microbiology Laboratory, 2013-08)Three novel human leukocyte antigen (HLA) alleles were identified using a sequence-based typing of HLA class I and class II alleles of 1867 participants from a male circumcision cohort in Kenya. The new alleles were first ... -
High pH reversed-phase chromatography as a superior fractionation scheme compared to off-gel isoelectric focusing for complex proteome analysis
(University of NairobiDepartment of Medical Microbiology, 2013-10)MS/MS is the technology of choice for analyzing complex protein mixtures. However, due to the intrinsic complexity and dynamic range present in higher eukaryotic proteomes, prefractionation is an important step to maximize ... -
HIV and Interferon Regulatory Factor 1: A Story of Manipulation and Control.
(University of NairobiDepartment of Medical Microbiology,, 2013-11)Members of the interferon regulatory factor (IRF) family control the expression of numerous proteins, many of which are central to regulating host immune responses. IRF1 is one of the central mediators of the innate and ... -
Validation of a modified version of the PRIME screen for psychosis-risk symptoms in a non-clinical Kenyan youth sample.
(ElsevierCollege of Health Sciences, 2013)The PRIME screen is a self-administered questionnaire designed to quickly assess individuals at risk for developing a psychotic disorder. It is shorter in both length and administration time compared to the Structured ... -
Anti-HIV-1 activity of elafin depends on its nuclear localization and altered innate immune activation in female genital epithelial cells.
(University of NairobiSchool of Medicine, 2012-12-27)Elafin (E) and its precursor trappin-2 (Tr) are alarm antiproteases with antimicrobial and immunomodulatory activities. Tr and E (Tr/E) have been associated with HIV-1 resistance. We recently showed that Tr/E reduced IL-8 ... -
Plasma and mucosal fluid from HIV type 1-infected patients but not from HIV type 1-exposed uninfected subjects prevent HIV type 1-exposed DC from infecting other target cells.
(University of NairobiDepartment of Medical Microbiology, 2007-01-23)Highly exposed persistently seronegative (HEPS) individuals have previously been shown to mount HIV-1-specific humoral and cellular immune responses in the mucosa, despite their uninfected status. It is thus possible that ... -
Acting locally: innate mucosal immunity in resistance to HIV-1 infection in Kenyan commercial sex workers
(University of NairobiDepartment of Medical Microbiology, 2013-06-26)Cohort studies of female commercial sex workers (CSWs) in Kenya were among the first to identify highly HIV-1-exposed seronegative (HESN) individuals. As natural resistance is usually mediated by innate immune mechanisms, ... -
The place of knowledge management in influencing lasting health change in Africa: an analysis of AMREF's progress.
(University of NairobiDepartment of Human Pathology, 2012)INTRODUCTION: AMREF (African Medical and Research Foundation) developed a Knowledge Management Strategy that focused on creating, capturing and applying health knowledge to close the gap between communities and health ... -
The impact of Fogarty International Center research training programs on public health policy and program development in Kenya and Uganda.
(University of NairobiUNITID, 2013-08)BACKGROUND: The Fogarty International Center (FIC) has supported research capacity development for over twenty years. While the mission of FIC is supporting and facilitating global health research conducted by U.S. and ... -
Wilms tumor survival in Kenya.
(University of NairobiSchool of Medicine, 2013-06)PURPOSE: Survival from Wilms Tumor (WT) exceeds 90% at 5 years in developed nations, whereas at last report, 2-year event-free survival (EFS) in Kenya reached only 35%. To clarify factors linked to these poor outcomes in ... -
Globulomaxillary cyst: a case report.
(School of Dental Sciences, 1972) -
How do Iranian emergency doctors decide? Clinical decision making processes in practice.
(University of Nairobischool of public health, 2012)INTRODUCTION: Emergency doctors must make decisions for many patients in a limited time. Various emergency cases are not compatible with routine conditions as described in textbooks, so doctors use clinical decision ... -
Dorsal dislocation of the first metatarsophalangeal joint associated with fractured second metatarsal head.
(University of Nairobischool of public health, 2011-06)Traumatic dislocations of the first metatarsophalangeal joint were first described by Mouchet in 1931. The anatomical complexity of the first metatarsophalangeal joint makes this injury one of a kind. There have been a ... -
Primary hydatid cyst of the thigh: on seven cases
(University of Nairobischool of public health, 2013-04)We report on seven cases that presented a benign soft-tissue mass in the thigh muscles. Ultrasonography provided the diagnosis of hydatid cyst. Total pericystecomy was performed. We point out the importance of preoperative ... -
Combinatorial prevention of HIV transmission in women: the case for a vaginal microbicide.
(University of Nairobischool of public health, 2011-07)Women are now becoming pivotal in the epidemiological spread of HIV infection throughout the world, especially in developing countries, where heterosexual transmission accounts for more than 80% of all new HIV infections. ... -
Temperament characteristics of street and non-street children in Eldoret, Kenya
(School of Medicine, University of Nairobi, 2004) -
Inhibition of double-stranded RNA-dependent protein kinase strongly decreases cytokine production and release in peripheral blood mononuclear cells from patients with Alzheimer's disease.
(University of NairobiSchool of Medicine, 2010)Alzheimer's disease (AD), a neurodegenerative disorder, is the most common form of dementia in the elderly individuals. Among the pathogenic mechanisms in AD, chronic systemic inflammation is described and characterized ... -
Nursing approach to a patient with chronic schizophrenia who has been left untreated
(College of Health Sciences, 1978) -
Spatial clustering and epidemiological aspects of visceral leishmaniasis in two endemic villages, Baringo District, Kenya
(College of Health Sciences, 2006)Visceral leishmaniasis (VL) seroprevalence in Kenya is unknown because of the lack of a practical and accurate diagnostic test or surveillance system. A novel serological assay was used to estimate the seroprevalence of ...