Faculty of Health Sciences (FHS): Recent submissions
Now showing items 2981-3000 of 10387
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Complete measurement of the pKa values of the carboxyl and imidazole groups in Bacillus circulans xylanase.
(University of NairobiFaculty of medicine, 1997-12)Electrostatic interactions in proteins can be dissected experimentally by determining the pKa values of their constituent ionizable amino acids. To complement previous studies of the glutamic acid and histidine residues ... -
Stability and oligosaccharide binding of the N1 cellulose-binding domain of Cellulomonas fimi endoglucanase CenC.
(University of NairobiFaculty of medicine, 1998-03)Differential scanning calorimetry has been used to study the thermal stability and oligosaccharide-binding thermodynamics of the N-terminal cellulose-binding domain of Cellulomonas fimi beta-1,4-glucanase CenC (CBDN1). ... -
The First Ten Years of Open Heart Surgery - Dilemmas, Tribulations and Possibilities
(University of NairobiCollege of Health science, 1992)This paper looks at the beginnings of cardiac surgery in Kenya with relevant clinical data as well as the overall historical background to various cardiovascular operations which preceded formal establishment of the Thoracic ... -
Spontaneous evacuation of an oesophageal foreign body after failed thoracotomy - MEDICOM
(University of NairobiCollege of Health science, 1998) -
Some rare lesions of the oesophagus - MEDICOM:
(University of NairobiCollege of Health science, 1999) -
Science and the man - MEDICOM
(University of NairobiCollege of Health science, 2002) -
Determinants of failure to access care in mothers referred to HIV treatment programs in Nairobi, Kenya
(University of NairobiFaculty of medicine, 2010)Background. As prevention of mother-to-child transmission of HIV (PMTCT) programs and HIV treatment programs rapidly expand in parallel, it is important to determine factors that influence the transition of HIV-infected ... -
Incident HSV-2 Infections Are Common Among HIV-1-discordant Couples.
(University of NairobiFaculty of medicine, 2013-07-21)Background. The synergy between herpes simplex virus type 2 (HSV-2) and human immunodeficiency virus type 1 (HIV-1) is well known, but lack of knowledge about the epidemiology of HSV-2 acquisition in HIV-1-discordant couples ... -
Comparing pap smear, via, and hpv cervical cancer screening methods among hiv-positive women by immune status and antiretroviral therapy.
(Faculty of medicine, 2013-07-09)A rigorous comparison of cervical cancer screening methods utilizing data on immune status, antiretroviral therapy (ART), and colposcopy-directed biopsy has not been performed among HIV-positive women. METHODS:: Between ... -
Hydrogen bonding and catalysis: a novel explanation for how a single amino acid substitution can change the pH optimum of a glycosidase.
(University of NairobiFaculty of medicine, 2000-05)The pH optima of family 11 xylanases are well correlated with the nature of the residue adjacent to the acid/base catalyst. In xylanases that function optimally under acidic conditions, this residue is aspartic acid, whereas ... -
Dissecting the electrostatic interactions and pH-dependent activity of a family 11 glycosidase.
(University of NairobiFaculty of medicine, 2001)Previous studies of the low molecular mass family 11 xylanase from Bacillus circulans show that the ionization state of the nucleophile (Glu78, pK(a) 4.6) and the acid/base catalyst (Glu172, pK(a) 6.7) gives rise to its ... -
Synthesis and in vivo antihyperglycemic activity of nature-mimicking furanyl-2-pyranones in STZ-S model.
(University of NairobiFaculty of medicine, 2007)Various nature-mimicking pyranones such as 6-(2,5-dimethylfuran-3-yl)-pyran-2-one and 6-(furan-2-yl)-pyran-2-one derivatives were synthesized and evaluated for their in vivo antihyperglycemic activity in sucrose-loaded ... -
Parasitic diseases: Liposomes and polymeric nanoparticles versus lipid nanoparticles.
(University of NairobiFaculty of medicine, 2007)Parasitic diseases such as malaria, leishmaniasis, and trypanosomiasis represent a significant global burden and pose a great challenge to drug discovery and delivery scientists due to their intracellular nature and ... -
Solid lipid nanoparticles (SLN) of tretinoin: potential in topical delivery.
(University of NairobiFaculty of medicine, 2007)The objective of this investigation was to develop solid lipid nanoparticles (SLN) of tretinoin (TRE) with the help of facile and simple emulsification-solvent diffusion (ESD) technique and to evaluate the viability of an ... -
Investigation of monovalent and bivalent enantioselective molecular recognition by electrospray ionization-mass spectrometry and tandem mass spectrometry.
(University of NairobiFaculty of medicine, 2008)In this work is described the investigation of bivalent versus monovalent enantioselective molecular recognition in the context of enantioselective separations. Electrospray ionization-mass spectrometry (ESI-MS) and tandem ... -
Lipid nanoparticles for parenteral delivery of actives.
(University of NairobiFaculty of medicine, 2008)The present review compiles the applications of lipid nanoparticles mainly solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and lipid drug conjugates (LDC) in parenteral delivery of pharmaceutical ... -
Synthesis of alpha-amyrin derivatives and their in vivo antihyperglycemic activity.
(University of NairobiFaculty of medicine, 2008)Ficus racemosa belongs to the family of Moraceae and is commonly known as 'Gular' in north India. Bio-activity guided isolation work on the fruits of F. racemosa resulted in the identification of antidiabetic active ... -
Direct targeting of the mucin 1 oncoprotein blocks survival and tumorigenicity of human breast carcinoma cells.
(University of NairobiFaculty of medicine, 2009)The mucin 1 (MUC1) oncoprotein is aberrantly overexpressed by approximately 90% of human breast cancers. However, there are no effective agents that directly inhibit MUC1 and induce death of breast cancer cells. We have ... -
MUC1-C oncoprotein functions as a direct activator of the nuclear factor-kappaB p65 transcription factor.
(University of NairobiFaculty of medicine, 2009)Nuclear factor-kappaB (NF-kappaB) is constitutively activated in diverse human malignancies. The mucin 1 (MUC1) oncoprotein is overexpressed in human carcinomas and, like NF-kappaB, blocks cell death and induces transformation. ... -
MUC1 oncoprotein is a druggable target in human prostate cancer cells.
(University of NairobiFaculty of medicine, 2009-11)Human prostate cancers are dependent on the androgen receptor for their progression. The MUC1 heterodimeric oncoprotein is aberrantly overexpressed in prostate cancers; however, it is not known if MUC1 is of functional ...