dc.contributor.author | Njagi, Joan M | |
dc.contributor.author | Ngugi, Mathew P | |
dc.contributor.author | Kibiti, Cromwell M | |
dc.contributor.author | Ngeranwa, Joseph | |
dc.contributor.author | Njue, Wilson | |
dc.contributor.author | Gathumbi, Peter | |
dc.contributor.author | Njagi, Eliud | |
dc.date.accessioned | 2015-04-10T12:59:32Z | |
dc.date.available | 2015-04-10T12:59:32Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Njagi, Joan Murugi, et al. "Hypoglycemic effect of Helichrysum odoratissimum in alloxan-induced diabetic mice." Journal of Phytopharmacology 4 (2015): 1-6. | en_US |
dc.identifier.uri | http://www.phytopharmajournal.com/Vol4_Issue1_06.pdf | |
dc.identifier.uri | http://hdl.handle.net/11295/82009 | |
dc.description.abstract | Diabetes mellitus is a disease of antiquity with worrying global incidence and prevalence. Conventional
management and/or treatment interventions have been hampered by drawbacks like high costs, i
naccessibility,
likelihood of potential adverse and toxic effects among others. Use of antidiabetic phytodrugs has been on the
rise, particularly in the developing countries, perhaps due to cost implications and accessibility advantages. In
this study, an
aqueous leaf extract of the medicinal plant
Helichrysum odoratissimum
was bioscreened for their
hypoglycemic potential in alloxan
-
induced diabetic mice. Three dose ranges were used viz; 50
mg/kgbwt, 100
mg/kgbwt and 150
mg/kgbwt. Results indicate that the
extract appreciably lowered blood glucose level in the
diabetic mice. The glucose lowering potency of this extract was dose dependent. Preliminary in vivo toxicity
assessment revealed that the plant has no discernible toxicity on the major organs of the st
udy animals. The
study results confirm the folklore reports from traditional medical practitioners that the extract has safe
bioactivity against diabetes mellitus. It avails an impetus for further bioscreening efforts with a view to the
development of more
hypoglycemic agents in future | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.subject | Diabetes mellitus, Diabetic mice, In - vivo toxicity, Aqueous leaf extract | en_US |
dc.title | Hypoglycemic effect of Helichrysum odoratissimum in alloxan induced diabetic mice | en_US |
dc.type | Article | en_US |
dc.type.material | en_US | en_US |