Mitochondrial oxidation rates and enzyme activities in the liver and brain of vitamin B12-deficient baboons
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Date
1975Author
Deana, R
Pearson, DJ
Siddons, RC
Verjee, ZH
Language
enMetadata
Show full item recordAbstract
Brain and liver samples were taken from 7 adult male Papio anubis after 32 months on a vitamin B-12 deficient diet of starch, sucrose, heated soya bean meal, cellulose, maize oil, mineral and vitamin supplements and ampicillin 50 mg/kg; 4 controls on the same diet received 2 mu g cyanocobalamin daily. In liver mitochondria of deprived baboons, propionyl-carnitine oxidation was unchanged whereas oxidation rates of other substrates, in particular succinate and heptanoate, were higher than those of controls; mitochondrial oxidation rates tended to be lower in brain of deprived baboons. Lipogenic enzymes were not significantly different in deprived and control baboons; acetylcholinesterase was unchanged in liver, but decreased in the brain of animals deprived of vitamin B-12.
URI
http://www.cabdirect.org/abstracts/19751435636.html?resultNumber=7&q=au%3A%22Verjee%2C+Z.+H.%22http://hdl.handle.net/11295/88332
Citation
International Journal of Biochemistry 1975 Vol. 6 No. 7 pp. 467-470Publisher
University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10378]