dc.contributor.author | Macharia-Mutie, Catherine | |
dc.contributor.author | Mwangi, Alice | |
dc.contributor.author | Brouwer, Inge | |
dc.date.accessioned | 2015-09-23T12:23:36Z | |
dc.date.available | 2015-09-23T12:23:36Z | |
dc.date.issued | 2015-08 | |
dc.identifier.citation | Macharia-Mutie, C., Mwangi, A., & Brouwer, I. (2015). Efficacy of Amaranth Grain Flour or Multi-micronutrient Fortified Maize Porridge on Iron of Kenyan Pre-school Children: A Randomized, Controlled Intervention. | en_US |
dc.identifier.uri | sciencedomain.org/download/MTA4MDJAQHBm | |
dc.identifier.uri | http://hdl.handle.net/11295/91372 | |
dc.description.abstract | Objectives: Adding iron-rich foods or multi-micronutrients powder (MNP) could be options to
control iron deficiency anaemia (IDA) in children. Data evaluating the impact of fortification with
iron-rich foods such as amaranth grain and MNP containing low doses of highly bio-available iron
to control IDA is limited. We assessed the efficacy of maize porridge enriched with amaranth grain
or MNP to reduce IDA in Kenyan pre-school children.
Methods: In a 16-week intervention trial, children (n=279; 12-59 months) were randomly assigned
to: unrefined maize porridge (control; 4.1 mg of iron/meal); unrefined maize (30%) and amaranth
grain (70%) porridge (amaranth group; 23 mg of iron/meal); or unrefined maize porridge with MNP
(MNP group; 6.6 mg iron/meal; 2.5 mg iron as NaFeEDTA). Primary outcomes were anaemia and
iron status with treatment effects estimated relative to control.
Results: At baseline, 38% were anaemic and 30% iron deficient. Consumption of MNP reduced
prevalence of anaemia [-46% (95% CI= -67,-12)], ID [-70% (95% CI=-89,-16)], IDA [-75% (95% CI=
-92,-20)] and soluble transferrin receptor [-10% (95% CI=-16,-4)] concentration while significantly
increasing haemoglobin [2.7 g/L (95% CI= 0.4, 5.1)] and plasma ferritin [40% (95% CI=10, 95)]
concentration. There was no significant change in haemoglobin or iron status in the amaranth group.
Conclusions: Consumption of maize porridge fortified with low dose highly bio-available iron MNP
can reduce the prevalence of IDA in pre-school children. In contrast, fortification with amaranth
grain even when shown to have high iron concentration without reduction of phytic acid may not
show significant improvement in iron status. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.title | Efficacy of amaranth grain flour or multi-micronutrient fortified maize porridge on iron of Kenyan Pre-school Children: A randomized, controlled intervention | en_US |
dc.type | Article | en_US |
dc.type.material | en | en_US |