| dc.description.abstract | There is little information available in man regarding gonadal vs. hypothalamic-pituitary contributions to malnutrition-related delayed puberty. To investigate this question, a cross-sectional study was made of 342 rural (R) and 358 urban (U) Kenyan (Bantu) chilren, ages 10-17. Comparative data in early pubertal girls revealed the following mean differences (p<.01) in anthropometry:
FSH and LH excretion (mIU/hr) was determined by radioimmunoassay of timed urine specimens. Mean gonadotropin values for individuals in middle and late pubertal stages were similar between the 2 nutritional groups. In early pubertal childhood, however, LH secretion (but not FSH) was lower in malnourished boys (50±7.0 vs. 76±5.5 mIU/hr, p<.05) and girls (55±8.8 vs. 99±12 mIU/hr, p<.01), equivalent to levels in the prepubertal, urban group. On the basis of age urinary gonadotropins were consistently lower in rural children 10-13 yr old. Conclusions: 1) The onset of puberty in man is not determined by size. 2) Gonadotropin relationships to age and pubertal stage in the 2 nutritional categories suggest pituitary rather than gonadal factors mediate the delayed onset of puberty associated with malnutrition. | en_US |
