dc.contributor.author | Kabubii, Zelipha N | |
dc.contributor.author | Mbaria, James M | |
dc.contributor.author | Mbaabu, Mathiu | |
dc.date.accessioned | 2015-11-30T06:14:33Z | |
dc.date.available | 2015-11-30T06:14:33Z | |
dc.date.issued | 2015-10 | |
dc.identifier.uri | http://journals.uonbi.ac.ke/ajpt/article/view/1392/1157 | |
dc.identifier.uri | http://hdl.handle.net/11295/92691 | |
dc.description.abstract | Background: The knowledge of the healing virtues of Catharanthus roseus and a host of other medicinal plants has
been in existence since ancient times. Catharanthus roseus is traditionally used more commonly as anti-diabetic and
anti-malaria remedy. Lack of adequate pharmacological and toxicological data of natural products to support their use
is a major setback.
Objective: To establish the acute toxicity effect of Catharanthus roseus crude aqueous extract on some hematological
and biochemical parameters.
Methodology: Catharanthus roseus aqueous extract was orally administered once to two groups of male rats at 1000
and 5000 mg/kg body weight respectively alongside a control group which received 2ml distilled water.
Hematological and biochemical assays were done at 48 hours and the 14th day. The data was analyzed using SPSS 17.0.
Results: White blood cells (WBC), creatinine, urea, alanine aminotransferase and aspartate aminotransferase showed
significant increase while mean cell volume reduced significantly at 48 hours in the high dose group. The body weight
change was also significantly reduced.
Discussion: The alterations of the body weight gain, various biochemical and hematological parameters reflect the
effect of toxicity after exposure of the tested extract doses. Total proteins concentration was not altered suggesting
that the renal and liver functions were not adversely affected. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Kabubii, Z. N., Mbaria, J. M., & Mbaabu, M. (2015). Acute toxicity studies of Catharanthus roseus aqueous extract in male Wistar rats. African Journal of Pharmacology and Therapeutics, 4(4). Pp. 130-134 | en_US |
dc.subject | Catharanthus roseus, acute toxicity, rats | en_US |
dc.title | Acute toxicity studies of Catharanthus roseus aqueous extract in male Wistar rats | en_US |
dc.type | Article | en_US |