The binder effect of povidone on the mechanical properties of paracetamol containing tablets
View/ Open
Date
2015-08Author
kithinji, Erick N
Type
ThesisLanguage
enMetadata
Show full item recordAbstract
BACKGROUND. Binders are excipients added either dry or in solution form to
drug-filler mixtures to provide cohesiveness. This ensures the intactness of the tablet
after compression. Materials with low or no cohesive qualities of their own will
require a stronger binder. Powder compression is the reduction in the volume of a
powder due to the application of a force.(Aulton M.E, 2013). The process of tablet
making involves optimization of input variables. Prior to compression, the tableting
mixture is characterized by particle size distribution analysis, measurement of the
true, bulk and tapped densities and evaluation of the flow properties. The mechanical
properties of the tablet are measured by resistance to crushing, friability and
disintegration tests
.PROBLEM STATEMENT. Elastic deformation is a reversible phenomenon
hindering tablet formation, whereas plastic deformation and brittle fracture of
particles are irreversible and promote tablet formation. Paracetamol mainly exhibits
particle fragmentation and high elastic deformation leading to tablet capping. Choice
of binder is a critical process in paracetamol tablet formulation.
OBJECTIVE. To study the effect of the binders povidone K90 and Povidone K30 on
the mechanical properties of paracetamol containing tablets.
METHOD. Granules containing a varying ratio of the binders povidone K90 and
povidone K30 were formulated. The flow properties of the granules were
determined. The mechanical properties of the tablets formed were studied.
Descriptive analysis was by bar charts and inferential analysis was by R statistical
software version 3.2.0.
RESULTS. Paracetamol containing tablets with 100% povidone K90 exhibits the
highest mechanical strength as measured by the crushing strength friability ratio
(CSFR). Paracetamol containing tablets with a binary mixture of povidone K90 and
povidone K30 in the ratio of 1:3 have the best mechanical properties as measured by
the crushing strength friability ratio: disintegration time (CSFR : DT).
CONCLUSION. A binary binder mixture of povidone K90 and povidone K30 in the
ratio of 1:3 produces paracetamol containing tablets with the best mechanical
properties and tablets with 100% povidone K90 have the highest mechanical
strength.
Publisher
University of Nairobi