Antihyperglycemic activity of zanthoxylum chalybeum stem bark extracts in diabetic rats
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Date
2015Author
Kimani, CN
Mbaria, JM
Suleiman, M
Gakuya, D
Kiama, SG
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Zanthoxylum
chalybeum
Engl. (Rutaceae) stem bark is used by communities in Africa and Asia to manage
diabetes mellitus. This study determined the anti
-
hyperglycemic effect of
Z. chalybeum
aqueous stem bark
extract in streptozotocin
-
induced diabetic rat. The plant was obtained from Machakos County, Kenya and a
stem bark extract prepared. Rats were divided into experimental (n=5), negative control (n=5) and positive
control groups (n=5). Dia
betes was induced in each rat in experimental groups by a single dose intraperitoneal
in
jection of Streptozotocin at 45
mg/kg body weight. The plant extract was administered orally to the
experimental rats at dosages of 10,
100 and 1000mg/kg body weight for
14 days. The negative control group
was left untreated while the positive control group was treated orally with glibenclamide (10mg/kg body
weight). The effect of the extract on blood glucose, body weight, food and water intake and oral glucose
tolerance
were determined in all rats in the experimental and control groups. The aqueous stem bark extract
exhibited significant antidiabetic activity compared to the untreated diabetic controls (P<0.05). Additionally,
there was no significant difference between th
e extract fed diabetic rats and the normal controls.
Furthermore,
extract treated diabetic animals recorded a comparatively decreased weight loss which was dose dependent.
These results suggest that the aqueous stem bark extract of
Z. chalybeum
possesses s
ignificant
antihyperglycemic activity. This study thus corroborates the traditional use of the plant for the management of
diabetes.
However, further studies are required to identify the active ingredient(s) and determine the mode of
action
Citation
Kimani, C. N., Mbaria, J. M., Suleiman, M., Gakuya, D., & Kiama, S. G. (2015). Antihyperglycemic activity of Zanthoxylum chalybeum stem bark extract in diabetic rats.Publisher
University of Nairobi