dc.contributor.author | Genga, EK | |
dc.contributor.author | Oyoo, GO | |
dc.contributor.author | Ezzi, MS | |
dc.date.accessioned | 2016-08-22T05:57:33Z | |
dc.date.available | 2016-08-22T05:57:33Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | African Journal of Rheumatology, Vol 4, No 2 (2016) | en_US |
dc.identifier.uri | http://www.ajol.info/index.php/ajr/article/view/139151 | |
dc.identifier.uri | http://hdl.handle.net/11295/97017 | |
dc.description.abstract | Objective: To review the efficacy and safety profile of methotrexate in rheumatoid arthritis.
Data source: Published original research work and reviews were searched in English related to efficacy and safety profile of methotrexate in rheumatoid arthritis.
Study design: Only articles that emphasis on efficacy and safety profile of methotrexate in rheumatoid arthritis.
Data extraction: Online and library searches done.
Data synthesis: Data added and summarized.
Conclusion: Methotrexate (MTX) has been the mainstay of treatment of patients with Rheumatoid Arthritis (RA). It has been used for over 50 years as the backbone in the treatment in a number of rheumatic diseases and thus it remains a gold standard of therapy for RA. Clinical trial results indicate that weekly low dose MTX is generally safe and effective in the treatment of RA. Factors that favour a good response to MTX are male gender, non-smoking, early disease stage, absence of previous DMARD use, lower baseline disease activity, concomitant corticosteroids, inflammatory biomarkers (TNF-α levels, ESR, CRP) and HLADRB1 shared epitope (SE)-negativity. Folate supplementation has been shown to reduce the risk of adverse events. | en_US |
dc.language.iso | en | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Methotrexate | en_US |
dc.subject | Rheumatoid arthritis | en_US |
dc.subject | Efficacy | en_US |
dc.subject | Safety profile | en_US |
dc.title | Insights into methotrexate in rheumatoid arthritis: a clinical review | en_US |
dc.type | Article | en_US |