In vitro antiplasmodial activity of selected Luo and Kuria medicinal plants
Date
2012Author
Owuor, B.O.
Ochanda J O.
Kokwaro, J.O.
Cheruiyot, A.C.
Yeda, R.A
Okudo, C.A.
Akala, H.M.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Ethnopharmacological relevance: Drug resist ance in malaria is a recur ring subj ect that th reaten s publi c
health glob ally. There is an urgent nee d to seek new antima larial ag ents. This stud y seeking new
antima larials from medic inal plan ts is guided by et hnobota ny.
Materials and methods: Medicina l plants of the Luo and K uria ethnic groups of Kenya with high usa ge
report s were screened in vitr o for th eir antiplas modial activity using th e SYB R Green I fluor escence
assa y (MSF assa y).
Results: The IC50 ’s for drugs and total pl ant extr acts ra nged from 0.012 17 to 10.679 m g/ml. Ex tracts
were more activ e on chloroqui ne s ensitive than re sistant Plasm odium falci parum strains. Tylosema
fassoglense, Ageratum conyzoides and Ocimum kilimandscharicum exh ibited promisin g results. Plectranthus
barbatus did not show activ ity.
Conclusion: Eth nobotan ical knowle dge wa s sufficie ntly reliab le for identif ying plant extr acts with
antipla smodial act ivity.
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/9831http://www.ncbi.nlm.nih.gov/pubmed/23041700
Publisher
Elsevier Centre for Biotechnology and Bioinformatics