University of Nairobi Institutional Repository: Recent submissions
Now showing items 2661-2680 of 115143
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Prevalence and functional profile of SARS-CoV-2 T cells in asymptomatic Kenyan adults
(University of Nairobi, 2023)BackgroundSARS-CoV-2 infection in Africa has been characterized by a less severe disease profile than what has been observed elsewhere, but the profile of SARS-CoV-2-specific adaptive immunity in these mainly asymptomatic ... -
Women's experiences of care after stillbirth and obstetric fistula: A phenomenological study in Kenya
(University of Nairobi, 2023)Background: Stillbirth and (obstetric) fistula are traumatic life events, commonly experienced together following an obstructed labour in low- and middle-income countries with limited access to maternity care. Few studies ... -
Spatial autocorrelation and hotspot analysis of natural radionuclides to study sediment transport
(University of Nairobi, 2023)Tracking sediment movement is typically done with artificial radionuclides. However, this can be environmentally harmful and does not allow for sediment classification. Naturally occurring radionuclides are consequently ... -
Boredom-understanding the emotion and its impact on our lives: an African perspective
(University of Nairobi, 2023) -
Evaluation of the antibacterial activity of selected Kenyan medicinal plant extract combinations against clinically important bacteria
(University of Nairobi, 2023)Background: Infectious diseases are a major global public health concern as antimicrobial resistance (AMR) currently accounts for more than 700,000 deaths per year worldwide. The emergence and spread of resistant bacterial ... -
High prevalence of vaccine-preventable anal human papillomavirus infections is associated with HIV infection among gay, bisexual, and men who have sex with men in Nairobi, Kenya
(University of Nairobi, 2023)Background: Human papillomavirus (HPV) infection is associated with anal cancers and is more prevalent in gay, bisexual, and men who have sex with men (gbMSM), partly due to their vulnerability to HIV infection. Baseline ... -
The femtech revolution-A new approach to pregnancy management: Digital transformation of maternity care-The hybrid e-health perinatal clinic addressing the unmet needs of low- and middle-income countries
(University of Nairobi, 2023)Prenatal care and infant mortality rates are crucial indicators of healthcare quality. However, millions of women in low-income countries lack access to adequate care. Factors such as high-risk pregnancies and unmanaged ... -
Community Insights in Phylogenetic HIV Research: The CIPHR Project Protocol
(University of Nairobi, 2023)Inferring HIV transmission networks from HIV sequences is gaining popularity in the field of HIV molecular epidemiology. However, HIV sequences are often analyzed at distance from those affected by HIV epidemics, namely ... -
In vivo antiplasmodial activities of stem bark extracts of Avicennia marina in Plasmodium berghei-infected mice
(University of Nairobi, 2023)Introduction: malaria remains the leading cause of morbidity and mortality in developing tropical and subtropical nations. Due to the emergence and spread of drug resistance to currently available drugs, there is a need ... -
Shaping the Future of Africa-china Engagement
(University of Nairobi, 2023)Chinese information communication technology (ICT) multinational corporations (MNCs) have built the backbone infrastructure used by millions of internet users across Africa and the world (Cisse, 2012; Oreglia, 2012; ... -
Reconstruction of a polyclonal ADCC antibody repertoire from an HIV-1 non-transmitting mother
(University of Nairobi, 2023)Human natural history and vaccine studies support a protective role of antibody dependent cellular cytotoxicity (ADCC) activity against many infectious diseases. One setting where this has consistently been observed is in ... -
Evolutionary mismatch and the role of GxE interactions in human disease
(University of Nairobi, 2023)Globally, we are witnessing the rise of complex, non-communicable diseases (NCDs) related to changes in our daily environments. Obesity, asthma, cardiovascular disease, and type 2 diabetes are part of a long list of ... -
Recalibrating prognostic models to improve predictions of in-hospital child mortality in resource-limited settings
(University of Nairobi, 2023)Background: In an external validation study, model recalibration is suggested once there is evidence of poor model calibration but with acceptable discriminatory abilities. We identified four models, namely RISC-Malawi ... -
Delayed breast cancer presentation, diagnosis, and treatment in Kenya
(University of Nairobi, 2023)Purpose: In this mixed-methods study, we evaluated the factors that contribute to delayed breast cancer (BC) diagnosis and treatment at a Kenyan hospital. Methods: Individuals with a diagnosis of BC, either as a referral ... -
Aflatoxin contamination of maize and groundnut in Burundi: Distribution of contamination, identification of causal agents and potential biocontrol genotypes of Aspergillus flavus
(University of Nairobi, 2023)Aflatoxin contamination of the staples maize and groundnut is a concern for health and economic impacts across sub-Saharan Africa. The current study (i) determined aflatoxin levels in maize and groundnut collected at harvest ... -
Challenges and Opportunities in the Genetic Analysis of Inherited Retinal Dystrophies in Africa, a Literature Review
(University of Nairobi, 2023)Inherited retinal dystrophies (IRDs) are a global problem that is largely unaddressed, especially in Africa. Black indigenous Africans are rarely represented in research that develops genetic tests and genetic therapies ... -
Assessment of gestational age at antenatal care visits among Kenyan women to inform delivery of a maternal respiratory syncytial virus (RSV) vaccine in low- and middle-income countries
(University of Nairobi, 2023)Background: Maternal respiratory syncytial virus (RSV) vaccines that are likely to be implementable in low- and middle-income countries (LMICs) are in final stages of clinical trials. Data on the number of women presenting ... -
The role of partners, parents and friends in shaping young women's reproductive choices in Peri-urban Nairobi: a qualitative study
(University of Nairobi, 2023)Background: Contraceptive use among young women in Nairobi remains low despite high general knowledge of family planning (FP) methods. This paper draws on social norms theory to explore the role of key influencers (partners, ... -
Prevalence of non-alcoholic fatty liver disease in overweight and obese children seeking ambulatory healthcare in Nairobi, Kenya
(University of Nairobi, 2023)Background: While linked to obesity and associated with an increased cardiovascular morbidity, non-alcoholic fatty liver disease (NAFLD) is an often-asymptomatic cause of chronic liver disease in children. Early detection ... -
Validation of the English and Swahili Adaptation of the Patient Health Questionnaire-9 for Use Among Adolescents in Kenya
(University of Nairobi, 2023)Purpose: Our study aimed to validate culturally adapted English and Swahili versions of the Patient Health Questionnaire-9 (PHQ-9) for use with adolescents in Kenya. Criterion validity was determined with clinician-administered ...