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dc.contributor.authorNjagi, L W
dc.contributor.authorNyaga, P N
dc.contributor.authorBebora, L C
dc.contributor.authorMbuthia, P G
dc.contributor.authorMinga, U M
dc.identifier.citationInternational Scholarly Research Network ISRN Veterinary Science Volume 2012, Article ID 253809, 6 pages doi:10.5402/2012/253809en
dc.description.abstractThis study was carried out to verify the possibility that ducks are sources of Newcastle disease (ND) virus infection for chickens in mixed flocks. Immunosuppressed (IS) and non immunosuppressed (NIS) birds, at three different antibody levels (medium, low and absent) were used; the titres having been induced through vaccination, and mmunosuppression done using dexamethazone. Each of the 3 respective groups was further divided into 2 groups of about 12 ducks each: one challenged with velogenic ND virus; the other not challenged. Selected ducks fromall groups had their antibody titresmonitored serially using hemagglutination inhibition test, while two birds from each of the challenged groups were killed and respective tissues processed for ND viral recovery, using chicken embryo fibroblasts. In general, antibody titres of IS and NIS challenged ducks were significantly higher than their unchallenged counterparts (P < 0.05). Non-challenged pre-immunised ducks had a progressive decrease in antibody levels; non-immunised ducks did not seroconvert. Newcastle disease virus was isolated from livers and kidneys of the challenged ducks throughout the experimental period; indicating a possibility of viral excretion, especially when the birds are stressed. It, therefore, provides another possible model of viral circulation within mixed flocks.en
dc.subjectNewcastle Diseaseen
dc.subjectVirus Persistenceen
dc.subjectDifferent Immune Statusen
dc.titleEffect of Immunosuppression on Newcastle Disease Virus Persistence in Ducks with Different Immune Statusen
local.publisherDepartment of Veterinary Pathology, Microbiology and Parasitology, Faculty of Veterinary Medicineen

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