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dc.contributor.authorObregon, C
dc.contributor.authorRothen-Rutishauser, B
dc.contributor.authorGitahi, S K
dc.contributor.authorGehr, P
dc.contributor.authorNicod, L P
dc.identifier.citationAmerican Journal of Pathology. 2006;169(6): 2127-36en
dc.descriptionJournal articleen
dc.description.abstractDendritic cells (DCs) can release microvesicles, but the latter's numbers, size, and fate are unclear. Fluorescently labeled DCs were visualized by laser-scanning microscopy. Using a Surpass algorithm, we were able to identify and quantify per cell several hundred microvesicles released from the surface of stimulated DCs. We show that most of these microvesicles are not of endocytic origin but result from budding of the plasma membrane, hence their name, exovesicle. Using a double vital staining, we show that exovesicles isolated from activated DCs can fuse with the membrane of resting DCs, thereby allowing them to present alloantigens to lymphocytes. We concluded that, within a few hours from their release, exovesicles may amplify local or distant adaptive immunological responseen
dc.subjectHuman activated dendriticen
dc.subjectCells fuseen
dc.subjectDendritic cellsen
dc.titleExovesicles from human activated dendritic cells (DCS) fuse with resting DCS allowing them to present allo-antigensen
local.publisherWangari Mathai Institute, University of Nairobien

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