A study of acetylation status using hydrallazine in African Hypertensives at Kenyatta National Hospital
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In the present study investigation of hydrallazine acetylator phenotype was undertaken for the first time in hypertensive Africans. A total of 25 randomly selected patients with moderate to severe hypertension participated in the phenoty- ping study. The phenotyping was done by administration of oral standard hydrallazine dose of l50mg/day. The 24 hour urinary MTP/hydrallazine ratio was used to categ..orise patients into slow and fast acetylators. Of the patients studied 69.9% were slow acetylators while 30.4% were fast acetylators. The mean 24 hour urinary MTP/hydrallazine ratio for slow acetylators was 1.0,1± 0.95 mean ± SD. This was significantly different from fast acetylator phenotype where the mean 24 hour urinary MTP/hydrallazine was 10.6±4.4 mean ±SD (P<O.OOl). The acetylator phenotyping divided the patients studied into two distinct populations and no further arbitrary method was required to divide the patient into either group.