Antimicrobial Activities of a New Schizozygane Indoline Alkaloid from Schizozygia coffaeoides and the Revised Structure of Isoschizogaline
Kariba R M.
Houghton P J.
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Extracts from Schizozygia coffaeoides showed antimicrobial activity against fungal and bacterial species. Alkaloids isolated using bioassay-guided fractionation were isoschizogaline, schizogynine, and a new indoline alkaloid, 7,8-dehydro-19β-hydroxyschizozygine, shown to be the most active antifungal compound. The structure of isoschizagaline, the only active antibacterial, is revised on the basis of NMR analysis.