Skin irritant diterpene orthoesters of the daphnane type from Peddiea africana and P. Volkensii
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From roots of Peddiea volkensii (Thymelaeaceae) the irritant factors V1 and V2 and from roots of P. africana the irritant factor A1 were isolated. Their structures are the 9,13,14-ortho-(2,4,6-decatrienoates) of 5β-hydroxyresiniferonol-6α,7α-oxide (V1) and of 5β,12β-dihydroxyresiniferonol-6α,7α-oxide (A1) and the 12-O-acetate of the latter (V2). Factors V1 and V2 do not exhibit tumour-promoting activity in the standard initiation-promotion protocol on mouse skin, although V1 is a moderate irritant.