The first 9-hydroxyhomoisoflav anone, and antiplasmodial chalcones, from the aerial exudates of Polygonum senegalense
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Phytochemical re-examination of the aerial exudates of Polygonum senegalense forma senegalense has resulted in the isolation and ch aracterization of a novel homoisoflavonoid, 5,7- dihydroxy-3-(hydroxy-phenyl-m ethyl)-6-methoxy-chroman-4- one (trivial name: polygohomoisoflavanone). The structure was determ ined on the basis of spectroscopic evidence. The new compound along with other component s of the aerial exudate showed good antiplasmodial activities towards chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum.