Antinociceptive, Antipyretic and anti-inflammatory effects of Solanum incanum linnaeus in animal models
The root of Solanum incanum is used by some Kenyan communities as a folklore remedy for fever, wound healing, fever and toothache. However scientific studies have not been done to validate these claims. The aim of this study was to investigate antinociceptive, antipyretic and anti-inflammatory effects of Solanum incanum root extract using animal models. The antinociceptive assay was carried out using hot plate and tail flick on white CBA mice. In the antipyretic assay fever was induced in Sprague Dawley rats using lipopolysaccharide (LPS) while carrageenan induced paw edema was used as the model for acute inflammation. The 100 and 200 mglKg dose of Solanum incanum root extract showed significant (p < 0.05) antinociceptive activity to both hot plate and tail flick tests The 50 mg/kg dose of Solanum incanum extract exhibited significant (p < 0.05) antipyretic effect at 180 minutes while the 100 mglKg dose of S. incanum exhibited significant antipyretic effect at 120 and 180 minutes after lipopolysaccharides pyrogen injection .. The 50, 100 and 200mg / Kg doses of Solanum incanum failed to show significant anti-inflammatory effects (p > 0.05) Therefore from these observations, it's highly probable that Solanum incanum root extract contains compounds with both antinociceptive and antipyretic but no anti-inflammatory effects. Hence this may render support to folklore use of Solanum incanum root extract for pain and fever.