Show simple item record

dc.contributor.authorKarim, F
dc.contributor.authorKanui, T I
dc.contributor.authorMbugua, S
dc.identifier.citationNeuroreport. 1993 Jan;4(1):25-8.en
dc.description.abstractA dilute solution of formalin (20 microliters of 10% formalin) was injected subcutaneously in the dorsal right hind paw of the naked mole-rat. The injection of the dilute formalin produced two periods of pain behaviour, the early (0-5 minutes) and the late phase (25-60 minutes). These were quantified as the total time spent licking the injected paw. Codeine phosphate (10, 25 or 50 mg kg-1) significantly reduced pain behaviour in both the early and late phase. Codeine administration also induced aggressive, hyperactive behaviour and motor impairment that was naloxone (2 mg kg-1) reversible. Naproxen (200 mg kg-1) and dexamethasone phosphate (30 mg kg-1) significantly reduced licking activity in the late phase only.en
dc.publisherUniversity of Nairobi.en
dc.titleEffects of codeine, naproxen and dexamethasone on formalin-induced pain in the naked mole-rat.en
local.publisherDepartment of Animal Physiologyen

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record