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    Dilated cardiomyopathy and myocarditis in Kenya: an endomyocardial biopsy study.

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    Date
    1993-09
    Author
    Sanderson, JE
    Olsen, EG
    Gatei, David
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    Abstract
    We have studied, by light and electron microscopy, left ventricular endomyocardial biopsy specimens from 18 African patients (14 men) with idiopathic dilated cardiomyopathy in Nairobi. Nine patients (50%) had evidence of healing myocarditis, that is the presence of a mild inflammatory cell infiltration within the myocardium. Interstitial fibrosis was prominent in five patients (28%) and in all 18 specimens there were hypertrophied muscle fibres. Therefore, half of the patients with idiopathic dilated cardiomyopathy had histological signs of a previous myocarditis. There was no serological evidence of a previous or recent coxsackie infection or any other common viral infections. It seems probable that the myocarditis was due to an inappropriate immunological reaction to myocardial muscle.
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    http://www.ncbi.nlm.nih.gov/pubmed/8282440
    http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/60850
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