• Login
    View Item 
    •   Repository Home
    • Journal Articles
    • College of Health Sciences (CHS)
    • View Item
    •   Repository Home
    • Journal Articles
    • College of Health Sciences (CHS)
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Depressed T-cell interferon-gamma responses in pulmonary tuberculosis: analysis of underlying mechanisms and modulation with therapy.

    Thumbnail
    View/Open
    Abstract.pdf (4.439Kb)
    Date
    1999-12
    Author
    Hirsch, CS
    Toossi, Z
    Othieno, Caleb
    Johnson, JL
    Schwander, SK
    Robertson, S
    Wallis, RS
    Edmonds, K
    Okwera, A
    Mugerwa, R
    Peters, P
    Ellner, JJ
    Metadata
    Show full item record
    Abstract
    Immunological and clinical profiles were evaluated in 2 groups: human immunodeficiency virus (HIV)-uninfected and HIV-infected patients, with newly diagnosed pulmonary tuberculosis (TB), and tuberculin-skin-test-reactive healthy control subjects. HIV-uninfected patients with TB were also followed up longitudinally during and after chemotherapy. At the time of diagnosis, purified protein derivative (PPD)-stimulated production of interferon (IFN)-gamma by peripheral blood mononuclear cells from TB patients was depressed, compared with that of healthy control subjects, whereas levels of transforming growth factor (TGF)-beta and interleukin (IL)-10 were increased. In longitudinal studies, PPD stimulated production of IL-10 and TGF-beta returned to baseline by 3 months, whereas IFN-gamma production remained depressed for at least 12 months. These data indicate that the immunosuppression of TB is not only immediate and apparently dependent (at least in part) on immunosuppressive cytokines early during the course of Mycobacterium TB infection but is also long lasting, presumably relating to a primary abnormality in T-cell function.
    URI
    http://www.ncbi.nlm.nih.gov/pubmed/10558973
    http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/60869
    Collections
    • College of Health Sciences (CHS) [9466]

    UoN Digital Archive copyright © 2002-2015  Library Department
    Contact Us | Send Feedback
     

     

    Browse

    All of RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    UoN Digital Archive copyright © 2002-2015  Library Department
    Contact Us | Send Feedback