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    Microbial Quality of Unregulated Herbal Medicinal Products in Kenya

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    Date
    2013
    Author
    Onyambu, Meshack O
    Chepkwony, Hezekiah K
    Thoithi, Grace N
    Ouya, Godfrey. O
    Osanjo, George O
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    Abstract
    Background: The use of herbal medicines is global, with the majority of the world’s population depending on traditional medicines, particularly herbal remedies for their primary healthcare needs. In Kenya, it is estimated that conventional healthcare system provides for approximately 30 % of the population, while nearly 70 % rely on herbal remedies. Herbal medicines, however, present safetyconcerns as they carry a relatively high risk of contamination by pathogenic microbes, organic and inorganic pollutants including toxic metals and non-metals, organic, mycotoxins, endotoxins, and agrochemical residues. Objective: This study was designed to assess the microbial quality of regulated and unregulated herbal medicinal products in diverse Kenyan markets, such as the supermarkets, roadside vendors, retail pharmacies and herbal clinics, for levels of microbial contaminants. Materials and Methods: Thirty samples of registered and unregistered herbal medicinal products were collected by purposive sampling from five Kenyan provinces. Microbial load analysis was performed in accordance topharmacopoeial methods (BP and USP). Microorganisms were further isolated and characterized using differential and selective media and by biochemical analyses. Results: All registered products had microbial load below 100 cfu/ml, and complied with BP and USP requirements. However, none of the unregistered samples complied with pharmacopoeial limits for either or both bacterial and fungal load limits. Most of the unregistered samples had microbial loads ranging from 3.00×106to 1.56 × 1010cfu/ml, thus exceeding by far BP or USP standards. The microbial isolates belonged to fifteen (15) different bacterial genera and seven (7) fungal genera. Escherichia coliwas the most frequently isolated bacteria from 75 % of the unregistered product samples while Klebsiella pneumoniae, Enterobacter aerogenes, and Staphylococcus aureusfollowed in 70 %, 60 % and 45 % of the samples, respectively. Salmonella spp was isolated in 40 % of the samples while Shigellaspp was found in 20 % of the samples. Conclusion: Unregulated herbal medicinal products that are available in diverse Kenyan markets show poor microbial quality and exhibit contamination by pathogenic microorganisms. There is need to extend regulatory control by the drug authorities to herbal medicinal products to enhance microbial quality and safety
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    http://journals.uonbi.ac.ke/files/journals/5/articles/1164/public/1164-4224-1-PB.pdf
    http://hdl.handle.net/11295/64911
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