Chemotherapy of malaria with special reference to drug interactions with chloroquine and herbal management of malaria in Kenya
Guantai, A N
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The first part of this project deals with chloroquine and its interactions with other drugs. A survey carried out in New Nyanza General Hospital (Kisumu, Kenya) a malaria endemic area, revealed that chloroquine was indeed the first line of management in the chemotherapy of malaria. The same survey indicated that chloroquine poisoning contributed to a total of 429 deaths in the above hospital within a span of seven years. Out of a sample of 1,153 patients treated in the outpatient clinic during-the survey period showed that 65.9% were adults. No sex variation in the treatment and incidence of malaria was noticed. Chloroquine dosage varied from an underdose of 6 by 250mg tablets in 3 days to an overdose of 20 by 250mg tablet in 5 days. Out of the analysed population 3.4% was given prophylactic treatment with a dose of 2 by 250mg chloroquine tablets weekly for a period ranging from 10 weeks to 6 months. Chloroquine drug combination therapy showed that the highest frequency was with aspirin at 23.12% followed by paracetamol with a frequency of 18.85%. This reveals that analgesic antipyretics are routinely given with chloroquine.