Possible Mechanism Of Action For Aldosterone-induced Hypertension
Burstyn, Peter G.
Horrobin, David F.
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Aldosterone applied locally to the carotid-sinus regions in rabbits produces a substantial rise in arterial pressure. The rise is larger and happens more quickly than when similar doses are given intravenously. Cross-circulation experiments confirm that the action is on the carotid-sinus regions and that it happens at dose levels comparable with secretion-rates seen in Conn's syndrome and malignant hypertension.