Inhibition By Tryptophan Of Nucleolar Rna Synthesis In Salivary Gland Nuclei Of Chironomus Thummi
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Tryptophan, but not glutamine and lysine, inhibits the incorporation of3H-uridine into nucleoli of explanted salivary glands by about 60%. In isolated nuclei also, the nucleolar incorporation of3H-uridine triphosphate is reduced to about 50% by tryptophan. It is concluded that tryptophan acts directly at the nuclear level and the possible mechanisms involved are discussed.