Three chalconoids and a pterocarpene from the roots of tephrosia aequilata.
dc.contributor.author | Atilaw, Y | |
dc.contributor.author | Duffy, S | |
dc.contributor.author | Heydenreich, M | |
dc.contributor.author | Muiva-Mutisya, L | |
dc.contributor.author | Avery, VM | |
dc.contributor.author | Erdélyi, M | |
dc.contributor.author | Yenesew, A | |
dc.date.accessioned | 2017-10-18T07:30:39Z | |
dc.date.available | 2017-10-18T07:30:39Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Molecules. 2017 Feb 20;22(2). pii: E318. doi: 10.3390/molecules22020318. | en_US |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/28230755 | |
dc.identifier.uri | http://www.mdpi.com/1420-3049/22/2/318/htm | |
dc.identifier.uri | http://hdl.handle.net/11295/101131 | |
dc.description.abstract | In our search for new antiplasmodial agents, the CH₂Cl₂/CH₃OH (1:1) extract of the roots of Tephrosia aequilata was investigated, and observed to cause 100% mortality of the chloroquine-sensitive (3D7) strain of Plasmodium falciparum at a 10 mg/mL concentration. From this extract three new chalconoids, E-2',6'-dimethoxy-3',4'-(2'',2''-dimethyl)pyranoretrochalcone (1, aequichalcone A), Z-2',6'-dimethoxy-3',4'-(2'',2''-dimethyl)pyranoretrochalcone (2, aequichalcone B), 4''-ethoxy-3''-hydroxypraecansone B (3, aequichalcone C) and a new pterocarpene, 3,4:8,9-dimethylenedioxy-6a,11a-pterocarpene (4), along with seven known compounds were isolated. The purified compounds were characterized by NMR spectroscopic and mass spectrometric analyses. Compound 1 slowly converts into 2 in solution, and thus the latter may have been enriched, or formed, during the extraction and separation process. The isomeric compounds 1 and 2 were both observed in the crude extract. Some of the isolated constituents showed good to moderate antiplasmodial activity against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Tephrosia aequilata; aequichalcone A; aequichalcone B; aequichalcone C; antiplasmodial; chalcone; pterocarpene; retrochalcone | en_US |
dc.title | Three chalconoids and a pterocarpene from the roots of tephrosia aequilata. | en_US |
dc.type | Article | en_US |
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