Study of anti-tuberculosis activity behaviour of natural Kaurane and trachylobane diterpenes compared with structural properties obtained by theoretical calculations
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Date
2017Author
Soares, ACF
Cabral, MMW
Martins, CHG
Ferreira, AE
Bergamo, PAS
Omosa, LK
Midiwo, JO
Heleno, VCG
Parreira, Renato L T
Type
ArticleLanguage
enMetadata
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A set of seven diterpenes, three kauranes and four trachylobanes, isolated from the African plant Psiadia punctulata were assayed against Mycobacterium tuberculosis and reached activity comparable with cycloserine, a second line drug used to treat tuberculosis (TB). Several structural properties of those diterpenes, such as lipophilicity, HOMO and LUMO energies, charge density, and intramolecular hydrogen bond (IHB) formation, were obtained by theoretical calculations and compared with their activities. Peculiar correlations were observed, especially between activity, lipophilicity and IHB formation.
Study of anti-tuberculosis activity behaviour of natural kaurane and trachylobane diterpenes compared with structural properties obtained by theoretical calculations (PDF Download Available). Available from: https://www.researchgate.net/publication/317750342_Study_of_anti-tuberculosis_activity_behaviour_of_natural_kaurane_and_trachylobane_diterpenes_compared_with_structural_properties_obtained_by_theoretical_calculations [accessed Oct 18 2017].
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https://profiles.uonbi.ac.ke/jmidiwo/publications/study-anti-tuberculosis-activity-behaviour-natural-kaurane-and-trachylobane-dithttps://www.researchgate.net/publication/317750342_Study_of_anti-tuberculosis_activity_behaviour_of_natural_kaurane_and_trachylobane_diterpenes_compared_with_structural_properties_obtained_by_theoretical_calculations
http://hdl.handle.net/11295/101138
Citation
Soares, Ana CF, et al. "Study of Anti-Tuberculosis Activity Behaviour of Natural Kaurane and Trachylobane Diterpenes Compared with Structural Properties Obtained by Theoretical Calculations." NATURAL PRODUCT COMMUNICATIONS 12.5 (2017): 763-769.Publisher
University of Nairobi
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Attribution-NonCommercial-NoDerivs 3.0 United StatesUsage Rights
http://creativecommons.org/licenses/by-nc-nd/3.0/us/Collections
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