dc.contributor.author | Wambui, JM | |
dc.contributor.author | Karuri, EG | |
dc.contributor.author | Ojiambo, JA | |
dc.contributor.author | Njage, PM | |
dc.date.accessioned | 2018-01-10T08:56:10Z | |
dc.date.available | 2018-01-10T08:56:10Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | 10.1080/01635581.2017.1247892. | en_US |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/27918845 | |
dc.identifier.uri | http://hdl.handle.net/11295/102299 | |
dc.description.abstract | Epidemiological studies show a definite connection between areas of high aflatoxin content and a high occurrence of human hepatocellular carcinoma (HCC). Hepatitis B virus in individuals further increases the risk of HCC. The two risk factors are prevalent in rural Kenya and continuously predispose the rural populations to HCC. A quantitative cancer risk assessment therefore quantified the levels at which potential pre- and postharvest interventions reduce the HCC risk attributable to consumption of contaminated maize and groundnuts. The assessment applied a probabilistic model to derive probability distributions of HCC cases and percentage reductions levels of the risk from secondary data. Contaminated maize and groundnuts contributed to 1,847 ± 514 and 158 ± 52 HCC cases per annum, respectively. The total contribution of both foods to the risk was additive as it resulted in 2,000 ± 518 cases per annum. Consumption and contamination levels contributed significantly to the risk whereby lower age groups were most affected. Nonetheless, pre- and postharvest interventions might reduce the risk by 23.0-83.4% and 4.8-95.1%, respectively. Therefore, chronic exposure to aflatoxins increases the HCC risk in rural Kenya, but a significant reduction of the risk can be achieved by applying specific pre- and postharvest interventions. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.title | Application of probabilistic modeling to quantify the reduction levels of hepatocellular carcinoma risk attributable to chronic aflatoxins exposure. | en_US |
dc.type | Article | en_US |