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dc.contributor.authorAldhaher, A
dc.contributor.authorLangat, M
dc.contributor.authorNdunda, B
dc.contributor.authorChirchir, D
dc.contributor.authorMidiwo, JO
dc.contributor.authorNjue, A
dc.contributor.authorSchwikkard, S
dc.contributor.authorCarew, M
dc.contributor.authorMulholland, D
dc.description.abstractFour previously undescribed diterpenoids including two crotofolanes, crotodichogamoin A and B, and two halimanes, crothalimene A and B, a new sesquiterpenoid, and fifteen previously reported compounds, including the crotofolane, crotohaumanoxide, the casbane, depressin, a further seven furanohalimane diterpenoids, three patchoulane and two further cadinane sesquiterpenoids and aleuritolic acid were isolated from the root of Croton dichogamus. Crotodichogamoin B is an important biosynthetic intermediate of the crotofolane class and this is the first report of patchoulene sesquiterpenoids from the genus. Compounds were tested at one concentration, 1 × 10-5 M, in the NCI59 cell one-dose screen but did not show significant activity snd were also evaluated for their cytotoxicity against Caco-2 cell lines using the neutral red assay. 10-epi-Maninsigin D reduced Caco-2 cell viability at 10, 30 and 100 μM, with values of decreased viability of 28%, 48% and 43% respectively. None of the other tested compounds showed significant activity.en_US
dc.publisherUniversity of Nairobien_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.subjectCaco-2 cell viability; Crothalimene A; Crothalimene B; Crotodichogamoin B; Crotofolane; Croton dichogamus; Euphorbiaceae; Patchoulaneen_US
dc.titleDiterpenoids from the roots of Croton dichogamus Pax.en_US

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Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States