Diterpenoids from the roots of Croton dichogamus Pax.
dc.contributor.author | Aldhaher, A | |
dc.contributor.author | Langat, M | |
dc.contributor.author | Ndunda, B | |
dc.contributor.author | Chirchir, D | |
dc.contributor.author | Midiwo, JO | |
dc.contributor.author | Njue, A | |
dc.contributor.author | Schwikkard, S | |
dc.contributor.author | Carew, M | |
dc.contributor.author | Mulholland, D | |
dc.date.accessioned | 2018-01-16T08:19:43Z | |
dc.date.available | 2018-01-16T08:19:43Z | |
dc.date.issued | 2017-12 | |
dc.identifier.citation | 10.1016/j.phytochem.2017.08.014. | en_US |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/28863305 | |
dc.identifier.uri | http://hdl.handle.net/11295/102365 | |
dc.description.abstract | Four previously undescribed diterpenoids including two crotofolanes, crotodichogamoin A and B, and two halimanes, crothalimene A and B, a new sesquiterpenoid, and fifteen previously reported compounds, including the crotofolane, crotohaumanoxide, the casbane, depressin, a further seven furanohalimane diterpenoids, three patchoulane and two further cadinane sesquiterpenoids and aleuritolic acid were isolated from the root of Croton dichogamus. Crotodichogamoin B is an important biosynthetic intermediate of the crotofolane class and this is the first report of patchoulene sesquiterpenoids from the genus. Compounds were tested at one concentration, 1 × 10-5 M, in the NCI59 cell one-dose screen but did not show significant activity snd were also evaluated for their cytotoxicity against Caco-2 cell lines using the neutral red assay. 10-epi-Maninsigin D reduced Caco-2 cell viability at 10, 30 and 100 μM, with values of decreased viability of 28%, 48% and 43% respectively. None of the other tested compounds showed significant activity. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Caco-2 cell viability; Crothalimene A; Crothalimene B; Crotodichogamoin B; Crotofolane; Croton dichogamus; Euphorbiaceae; Patchoulane | en_US |
dc.title | Diterpenoids from the roots of Croton dichogamus Pax. | en_US |
dc.type | Article | en_US |
Files in this item
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |