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Preclinical drug evaluation system in the Plasmodium knowlesi baboon model of malaria: the methotrexate study
(University of Nairobi, 2013)
Drug resistance against first-line antimalarials warrants search for new lead compounds and repurposing of drugs such as methotrexate. Animal models are required for preclinical drug development before clinical testing. ...
Dosing regimens of oral ciprofloxacin for children with severe malnutrition: a population pharmacokinetic study with Monte Carlo simulation
(University of Nairobi, 2011)
BACKGROUND:
Severe malnutrition is frequently complicated by sepsis, leading to high case fatality. Oral ciprofloxacin is a potential alternative to the standard parenteral ampicillin/gentamicin combination, but its ...
Clinical and neurophysiologic features of active convulsive epilepsy in rural Kenya: a population-based study
(University of Nairobi, 2010)
Purpose
Epilepsy is common in sub-Saharan Africa but is poorly characterized. Most studies are hospital-based, and may not reflect the situation in rural areas with limited access to medical care. We examined people with ...