Influence of host blood and its digestive products on Tryponosome differentiation In Tsetse fly, glossina morsitans morsitans Westood

Abstract

When tsetse feed on infected host, the ingestion bloodstream trypanosomes undergo a complex developmental process that leads to the formation of the metacyclic forms. Tsetse are obligatory bloodfeeders and display host preferences in their feeding behaviour. Therefore, host blood is an important factor in the transmission of trypanosomiasis. Host blood at the ineffective meals has been shown to influence trypanosome in tsetse. How, the host blood affect trypanosome development, particularly the transformation of bloodstream to procyclic forms, has not been previously established. Therefore, this study investigated how host blood and some of its digestive products influence this process. Moreover, since trypsin is one of the bloodmeal induced molecules implicated in the transformation process., this study also investigated the release of midgut trypsin by host blood and blood fractions..................................................