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Ethnic Differences In Thiopurine Methyltransferase Pharmacogenetics: Evidence For Allele Specificity In Caucasian And Kenyan Subjects.
(University of Nairobi, 1999-12)
Thiopurine methyltransferase (TPMT) degrades 6-mercaptopurine, azathioprine and 6-thioguanine which are commonly used in the treatment of autoimmune diseases, leukaemia and organ transplantation. TPMT activity is polymorphic ...