Pharmacokinetics of albendazole in children with hydatid disease
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Date
1993Author
Okelo, G B A
Hagos, B
Nga'nga, J N
Ogeto, John O
Type
ArticleLanguage
enMetadata
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The pharmacokinetics of albendazole were investigated in five children who were hospitalized at the Kenyatta National hospital for the treatment of hydatid disease.
unchanged albendazole was below detectable level in plasma. The major metabolite present was albendazole sulphoxide. In one of the patients, the concentration of albendazole sulphone in plasrna was significantly high, whereas in the other four children, only trace amounts were detected. Maximum concentrations of albendazole sulphoxide in these five children were variable and generally higher than those reported in adult. by other workers. Other pharmacokinetic parameters were comparable to those found in other studies .
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10601http://www.ncbi.nlm.nih.gov/pubmed/8187662
Citation
East African Medical Journal Vol. 70 No.10 October 1993Publisher
Department of Pharmacy. University of Nairobi, Department of clinical pharmacology,University of Nairobi