Show simple item record

Two Lignans Derivatives and Two Fusicoccane Diterpenoids From the Whole Plant of Hypoestes Verticillaris (L.f.) Sol. Ex Roem. & Schult

dc.contributor.authorOmole, Ruth A
dc.contributor.authorMainen, Julius Moshi
dc.contributor.authorMatthias, Heydenreich
dc.contributor.authorHamisi, Masanja M
dc.contributor.authorGathirwa, Jeremiah W
dc.contributor.authorOchieng, Sharon A
dc.contributor.authorOmosa, Leonida K
dc.contributor.authorMidiwo, Jacob O
dc.date.accessioned2019-03-19T04:14:17Z
dc.date.available2019-03-19T04:14:17Z
dc.date.issued2019
dc.identifier.citationOmole, Ruth Anyango, et al. "Two lignans derivatives and two fusicoccane diterpenoids from the whole plant of Hypoestes verticillaris (LF) Sol. Ex roem. & schult." Phytochemistry Letters 30 (2019): 194-200.en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1874390018307274
dc.identifier.urihttp://hdl.handle.net/11295/106445
dc.description.abstractBioassay-guided screening of Hypoestes verticillaris whole plant CH2Cl2:MeOH (1:1) extract for anti-plasmodial activity yielded four new compounds: two lignans 2, 6-dimethoxysavinin (1), 2,6-dimethoxy-(7E)-7,8-dehydroheliobuphthalmin (2); and two fusicoccane diterpenoids: 11(12)-epoxyhypoestenone (3) and 3(11)-epoxyhypoestenone (4). The chemical structures were determined using various spectroscopic techniques: UV–vis, IR, CD, 1D, 2D and MS. Two fractions (RAO-43B and RAO-43D) and the isolated compounds were tested for activity against CQ susceptible (D6) and resistant (W2) Plasmodium falciparum parasite strains, in vitro and the IC50 values determined. While the whole extract and some resultant fractions displayed moderate activity, the isolated compounds exhibited mild anti-plasmodial activity against the both strains ranging from IC50 value of 328 μM in 1 to 93 μM in 3 against W2 strain. Graphical abstract Hypoestes verticillaris..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................en_US
dc.language.isoenen_US
dc.publisherUniversity of Nairobien_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectFusicoccane diterpenes Lignans Hypoestes verticillaris Anti-Plasmodial activityen_US
dc.titleTwo Lignans Derivatives and Two Fusicoccane Diterpenoids From the Whole Plant of Hypoestes Verticillaris (L.f.) Sol. Ex Roem. & Schulten_US
dc.typeArticleen_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States