| dc.description.abstract | Anthelmintic activity of the water extracts ofAlbizia
anthelmintica bark and Maerua_edulis root was
evaluated in mice thathad been experimentally
infected with the intestinal nematode
Heligmosomoides polygyrus. The mice were
randomly allocated into six treatment groups and one
control group. Groups 1, 2 and 3 were given an oral
dose of water extracts of A. anthelmintica at 5gm1
kg, 10gmlkg and 20gm/kg bodyweight respectively
in a divided dose on day 17 post-infection. Groups 4,
5 and 6 were given water extracts of M edulis at a
dosage of 5gmlkg, 1Ogmlkg and 20gmlkg bodyweight
respectively in a divided dose. Group 7 was the
control and was concurrently given a double oral dose
of 0.2ml of physiological.saline each. Mortality of
some mice was observed in four groups after
treatment. Five days after treatment, faecal worm
egg count reduction was determined. The results
showed a percentage faecal H polygyrus egg count
reduction of 72%, 69%,50%,42% in groups 2,6,3,
and 1 respectively. Seven days after treatment there
was a reduction in worm counts at postmortem of
68%,36%,20%,19%,16% and 14% in groups 1,5,2,
3,6 and 4 respectively compared to untreated controls.
These results indicate that the plant extracts had
anthelmintic activity and support the use of these
plants as anthelmintics. | en |
