Electron transfer properties of 2-acetylferrocenyl2-thiophenecarboxylsemicarbazone and its copper (ii) complex
Date
2011Author
Guto, P M
Kiratu, J M
Daniel, L S
Kiremire, E M R
Kamau, G N
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
This work is aimed at obtaining the electrochemical properties of 2-acetylferrocenyl-2thiophenecarboxylsemicarbazone
(LH) and Copper (II) complex of 2-acetylferrocenyl-2thiophenecarboxylsemicarbazone
(CuL2), which were there earlier found to have different biological
activities against malaria parasites. Cyclic voltammetric studies on these compounds (LH and CuL2)
mainly gave one peak for each of the cathodic and anodic scans. These reduction/oxidation responses were
attributed to FeIII/FeII for LH and CuII/Cu1 for CuL2 redox couples. The mid-point potentials were found
to be +0.536 V for LH and -0.350 V for CuL2 versus Ag/AgCl. Literature shows that more positive redox
potentials than negative potentials are associated with higher biological activities. The average peak
separations for LH and CuL2 were found to be ~48 mV and ~363 mV between the scan rates of 0.01 V/s
and 0.1 V/s while their diffusion coefficients were 5.21 x 10-7 cm2/s and 2.67 x 10-7 cm2/s, respectively. This
difference in diffusion coefficients was attributed partially to the differences in their molecular weights
and the overall geometry, whereby CuL2 was almost double that of LH. The rates of electron transfer
constants were also found to be 12.3 cm/s for LH and 1.0 cm/s for CuL2.
Citation
International Journal of BioChemiPhysics, Vol. 19Publisher
Chemistry
Subject
Electron transfer properties2-acetylferrocenyl2-thiophenecarboxylsemicarbazone
copper (ii) complex