| dc.contributor.author | Yusuf, Amir O. | |
| dc.contributor.author | Bhatt, Bhalendu M. | |
| dc.contributor.author | Gitu, Peter M. | |
| dc.date.accessioned | 2013-02-26T15:33:43Z | |
| dc.date.issued | 2004 | |
| dc.identifier.citation | Journal of the Kenya Chemical Society, VoL2 No.1 | en |
| dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/11889 | |
| dc.description.abstract | Mesotocin, a nonapeptide amide, was synthesised on a benzhydryl-resin using the Boc-strategy. Benzyl group was use~ in the
protection of the side-chains of tyrosine and cysteine. Tetralinyl and benzhydryl groups were used to protect asparagtne and
glutamine side-chains respectively. TFMSA-TFA-thioanisole-I,2-ethanedithiol (2:20:2: I v/v) was used on the peptide-resin un~er
different cleavage conditions to obtain mesotocin in a one-pot reaction. The cleavage at 40 'Cfor two hours gave crude mesotocm,
which onpurification by semi-preparative HPLC gave ayield of 49 %. | en |
| dc.language.iso | en | en |
| dc.subject | side-chains | en |
| dc.subject | solid-phase peptide synthesis | en |
| dc.subject | cleavage conditions | en |
| dc.subject | amide-protecting | en |
| dc.subject | tetralinyl | en |
| dc.subject | electrospray mass spectrum | en |
| dc.title | I-Tetralinyl Group for Asparagine Side-Chain Protection, and Application to Bee-SolidPhase Peptide Synthesis of Mesotocin | en |
| dc.type | Article | en |
| local.publisher | Chemistry | en |
