Quinolizidine Alkaloids from Sophora velutina subsp. zimbabweensis (Fabaceae: Sophoreae)
Date
2012Author
Korira, Erick
Kiplimoa, Joyce J.
Croucha, Neil R.
Moodleyc, Nivan
Koorbanallya, Neil. A.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Three novel quinolizidine alkaloids, N-methylenehydroxycytisine (1), 6,7-dihydroxylupanine (2), and velutinine (3) have been isolated from the fruits and pods
(1 and 2) and stem bark (3) of Sophora velutina subsp. zimbabweensis along with the known quinolizidine alkaloids, 7-hydroxylupanine (4), thermopsine (5),
N-methylcytisine (6), cytisine (7), an aromatic ester, methyl-3-(3',4'-dimethoxyphenyl)-2-propenoate (8) and the triterpenoids, lup-20(29)-ene-3β-ol (9) and
12-oleanen-3-one (10). Compounds 6 and 10 showed good antibacterial activity against E. faecalis, with MIC values of 20.8 and 10.9 μg mL-1, respectively.
The other compounds tested exhibited low to moderate antibacterial activity.
Citation
Natural Product Communications Vol. 7 (8) pp. 971-1116 2012Publisher
Natural Product Communications Chemistry
Subject
Sophora velutina subsp. zimbabweensisFabaceae
N-methylenehydroxycytisine
Velutinine
6,7-Dihydroxylupanine